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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-8-17
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pubmed:abstractText |
New blood vessel formation, or angiogenic switch, is an essential event in the development of solid tumors and their metastatic growth. Tumor blood vessel formation and remodeling is a complex and multi-step processes. The differentiation and recruitment of mural cells including vascular smooth muscle cells and pericytes are essential steps in tumor angiogenesis. However, the role of tumor cells in differentiation and recruitment of mural cells has not yet been fully elucidated. This study focuses on the role of human tumor cells in governing the differentiation of mouse mesenchymal stem cells (MSCs) to pericytes and their recruitment in the tumor angiogenesis process.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1476-4598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
209
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pubmed:meshHeading |
pubmed-meshheading:20687910-Animals,
pubmed-meshheading:20687910-Cell Differentiation,
pubmed-meshheading:20687910-Cell Line,
pubmed-meshheading:20687910-Culture Media, Conditioned,
pubmed-meshheading:20687910-Mesenchymal Stem Cells,
pubmed-meshheading:20687910-Mice,
pubmed-meshheading:20687910-Mice, Inbred C3H,
pubmed-meshheading:20687910-Neuropilin-1,
pubmed-meshheading:20687910-Pericytes,
pubmed-meshheading:20687910-Proto-Oncogene Proteins c-sis
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pubmed:year |
2010
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pubmed:articleTitle |
Tumor cell-derived PDGF-B potentiates mouse mesenchymal stem cells-pericytes transition and recruitment through an interaction with NRP-1.
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pubmed:affiliation |
Cancer Research Unit, VA Medical Center, 4801 Linwood Blvd, Kansas City, Missouri 64128, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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