Linked Life Data

20686939

Source:http://linkedlifedata.com/resource/pubmed/id/20686939

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-8-5
pubmed:abstractText
RNAi is a mechanism displayed by most eukaryotic cells to rid themselves of foreign double-strand RNA molecules. In the 11 years since the initial report, RNAi has now been demonstrated to function in mammalian cells to alter gene expression and used as a means for genetic discovery as well as a possible strategy for genetic correction and genetic therapy in cancer and other diseases. The aim of this review is to provide a general overview of how RNAi suppresses gene expression, examine some published RNAi approaches that have resulted in changes in stem cell function, and suggest the possible clinical relevance of this work in cancer therapy through targeting cancer stem cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1940-6029
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
650
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3-14
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
RNAi in stem cells: current status and future perspectives.
pubmed:affiliation
Department of Pathology and Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural