Source:http://linkedlifedata.com/resource/pubmed/id/20685489
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2010-8-5
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pubmed:abstractText |
A direct HPLC enantioseparation of three new chiral oxadiazoline derivatives endowed with potential MAO-B inhibitory activity was accomplished on the immobilised Chiralpak IA chiral stationary phase. Multi-mg amounts of enantiomers with high enantiomeric purity (ee> or =98%) were rapidly collected using pure dichloromethane as eluent. The absolute configuration and chiroptical properties of the enantiomers isolated at semipreparative scale were exhaustively determined.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1873-3573
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2010 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
426-31
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pubmed:meshHeading |
pubmed-meshheading:20685489-Amylose,
pubmed-meshheading:20685489-Chromatography, High Pressure Liquid,
pubmed-meshheading:20685489-Drug Evaluation, Preclinical,
pubmed-meshheading:20685489-Monoamine Oxidase,
pubmed-meshheading:20685489-Monoamine Oxidase Inhibitors,
pubmed-meshheading:20685489-Oxadiazoles,
pubmed-meshheading:20685489-Stereoisomerism
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pubmed:year |
2010
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pubmed:articleTitle |
Application of an immobilised amylose-based chiral stationary phase to the development of new monoamine oxidase B inhibitors.
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pubmed:affiliation |
Istituto Superiore di Sanità, Dipartimento del Farmaco, Viale Regina Elena 299, 00161 Rome, Italy.
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pubmed:publicationType |
Journal Article
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