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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-9-6
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pubmed:abstractText |
We retrospectively analyzed outcomes among 1206 patients with hematologic malignancies who had hematopoietic cell transplantation (HCT) from HLA-identical siblings (n = 630) or HLA-matched unrelated donors (n = 576) at a single institution between 2001 and 2007 for a correlation between recipient statin use and risk of graft-versus-host disease (GVHD). Among recipients with cyclosporine-based postgrafting immunosuppression (n = 821), statin use at the time of transplant (6%) was associated with a decreased risk of extensive chronic GVHD (cGVHD) (multivariate hazard ratio [HR], 0.62; 95% confidence interval [CI], 0.4-1.0; P = .05) and an increased risk of recurrent malignancy (HR, 1.75; 95% CI, 1.0-3.0; P = .04). Recipient statin use, however, had no apparent impact on the risks of cGVHD and recurrent malignancy among recipients given tacrolimus-based immunosuppression (n = 385; 8% statin treated). Risks of acute GVHD, nonrelapse mortality, and overall mortality were not significantly affected by recipient statin use. Hence, recipient statin treatment at the time of allogeneic HCT may decrease the risk of cGVHD in patients with cyclosporine-based immunosuppression, but at the expense of a compromised graft-versus-tumor effect.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1523-6536
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pubmed:author |
pubmed-author:AppelbaumFrederick RFR,
pubmed-author:DeegH JoachimHJ,
pubmed-author:FlowersMary E DME,
pubmed-author:MaloneyDavid GDG,
pubmed-author:MartinPaul JPJ,
pubmed-author:MielcarekMarcoM,
pubmed-author:PefferAmandaA,
pubmed-author:RottaMarcelloM,
pubmed-author:SandmaierBrenda MBM,
pubmed-author:StorbRainerR,
pubmed-author:StorerBarry EBE,
pubmed-author:VernonMiwa SMS
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pubmed:copyrightInfo |
Copyright © 2010 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1463-6
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pubmed:dateRevised |
2011-10-3
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pubmed:meshHeading |
pubmed-meshheading:20685260-Adult,
pubmed-meshheading:20685260-Aged,
pubmed-meshheading:20685260-Chronic Disease,
pubmed-meshheading:20685260-Cyclosporine,
pubmed-meshheading:20685260-Drug Interactions,
pubmed-meshheading:20685260-Female,
pubmed-meshheading:20685260-Graft vs Host Disease,
pubmed-meshheading:20685260-Graft vs Tumor Effect,
pubmed-meshheading:20685260-Hematologic Neoplasms,
pubmed-meshheading:20685260-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:20685260-Humans,
pubmed-meshheading:20685260-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:20685260-Immunosuppressive Agents,
pubmed-meshheading:20685260-Incidence,
pubmed-meshheading:20685260-Male,
pubmed-meshheading:20685260-Middle Aged,
pubmed-meshheading:20685260-Recurrence,
pubmed-meshheading:20685260-Retrospective Studies,
pubmed-meshheading:20685260-Risk,
pubmed-meshheading:20685260-T-Lymphocytes,
pubmed-meshheading:20685260-Transplantation, Homologous,
pubmed-meshheading:20685260-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Impact of recipient statin treatment on graft-versus-host disease after allogeneic hematopoietic cell transplantation.
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pubmed:affiliation |
Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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