Linked Life Data

20685106

Source:http://linkedlifedata.com/resource/pubmed/id/20685106

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-9-27
pubmed:abstractText
The authors describe a proposed 15-?m-sized, single-cellular-level, and cell-manipulatable microplasma jet device with a microcapillary glass tip and its potential in the development of cancer treatment therapies. The electrical and optical properties of the plasma jets and preliminary apoptosis results of cultured murine tumor cells and non-tumor fibroblast cells treated with the plasma jets are presented. The generated plasma jet was stable and enabled the treatment of cultured cells in cell culture plates regardless of the small inner diameter and low gas flow rate. The microplasma jet was observed inducing apoptosis in cultured murine melanoma tumor cells in a dose-dependent manner. Furthermore, the percentage of apoptotic cells of murine melanoma tumor cells induced by this plasma device was approximately 2.5 times bigger than that of murine fibroblast cells as indicated by an Annex V apoptosis assay. The apoptosis in cultured murine tumor cells by the 15-?m-sized single-cellular-level and cell-manipulatable microplasma jet device was also observed using an in situ apoptosis assay. We report on a novel microplasma jet device with the advantages of single-cellular-level and single cell-manipulatable plasma treatment with precise and solid stimuli. This highly precise plasma medicine, which enables new directed cancer therapies can be combined with current cell manipulation and cell culturing technologies without much difficulty.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1873-4235
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
555-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
15-?m-sized single-cellular-level and cell-manipulatable microplasma jet in cancer therapies.
pubmed:affiliation
Holcombe Department of Electrical and Computer Engineering, Center for Optical Materials Science and Engineering Technologies (COMSET), Clemson University, Clemson, SC 29634, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't