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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-11-2
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pubmed:abstractText |
C-C chemokine receptor 5 (CCR5) plays an important role in inflammation. A 32 base-pair (?32) deletion in the CCR5 gene leads to a nonfunctional receptor. This deletion has been reported to have a protective effect on the development and progression of several autoimmune diseases. We investigated whether the ?32 deletion is associated with disease susceptibility in a population of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and lupus nephritis (LN); and whether it is associated with disease severity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0315-162X
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pubmed:author |
pubmed-author:BerdenJo H MJH,
pubmed-author:BergerStefan PSP,
pubmed-author:BijlMarcM,
pubmed-author:BrouwerElisabethE,
pubmed-author:DerksenRonald H W MRH,
pubmed-author:GrossSachaS,
pubmed-author:KallenbergCees G MCG,
pubmed-author:MartensHenk AHA,
pubmed-author:NavisGerjan JGJ,
pubmed-author:VoskuylAlexandre EAE,
pubmed-author:de SevauxRuudR,
pubmed-author:van der SteegeGerritG
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2226-31
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pubmed:meshHeading |
pubmed-meshheading:20682662-Adult,
pubmed-meshheading:20682662-Aged,
pubmed-meshheading:20682662-Alleles,
pubmed-meshheading:20682662-Arthritis, Rheumatoid,
pubmed-meshheading:20682662-Base Sequence,
pubmed-meshheading:20682662-Chi-Square Distribution,
pubmed-meshheading:20682662-Female,
pubmed-meshheading:20682662-Gene Frequency,
pubmed-meshheading:20682662-Genetic Association Studies,
pubmed-meshheading:20682662-Genotype,
pubmed-meshheading:20682662-Humans,
pubmed-meshheading:20682662-Lupus Erythematosus, Systemic,
pubmed-meshheading:20682662-Lupus Nephritis,
pubmed-meshheading:20682662-Male,
pubmed-meshheading:20682662-Middle Aged,
pubmed-meshheading:20682662-Polymerase Chain Reaction,
pubmed-meshheading:20682662-Receptors, CCR5,
pubmed-meshheading:20682662-Sequence Deletion,
pubmed-meshheading:20682662-Severity of Illness Index,
pubmed-meshheading:20682662-Statistics, Nonparametric
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pubmed:year |
2010
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pubmed:articleTitle |
Lack of association of C-C chemokine receptor 5 ?32 deletion status with rheumatoid arthritis, systemic lupus erythematosus, lupus nephritis, and disease severity.
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pubmed:affiliation |
Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands. h.martens@maartenskliniek.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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