Source:http://linkedlifedata.com/resource/pubmed/id/20679526
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
20
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| pubmed:dateCreated |
2010-11-22
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| pubmed:abstractText |
The role of circulating cytokines and chemokines (C&Ckine) in activating signal transduction in leukemic cells is incompletely defined. We hypothesized that comprehensive profiling of C&Ckine expression in leukemia would provide greater insight compared with individual analyses. We used multiplex array technology to simultaneously measure the level of 27 C&Ckines in serum from 176 acute myelogenous leukemia (AML) and 114 myelodysplastic syndrome (MDS) patients and 19 normal controls. C&Ckine levels in AML and MDS differed significantly from normal controls (5 higher, 13 lower) but were similar to each other for 24 of 27 analytes, with interleukin-8 and interleukin-13 higher in AML and vascular endothelial growth factor A higher in MDS. Levels did not correlate with age, gender, infection, or blood counts; however, 3 correlated with specific cytognetic abnormalities in AML. Individually, few cytokines had any correlation with response or survival. In newly diagnosed AML, 8 C&Ckine signatures, distinct from the normal control signature, were observed. These signatures had prognostic impact, affecting remission, primary resistance, relapse rates, and overall survival, individually (P = .003) and in multivariable analysis (P = .004). These patterns suggest specific therapeutic interventions to investigate in subsets of AML patients. In conclusion, C&Ckine expression in AML and MDS differs from normal, is similar with one another, and forms recurrent patterns of expression with prognostic relevance.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1528-0020
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
18
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| pubmed:volume |
116
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
4251-61
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| pubmed:meshHeading |
pubmed-meshheading:20679526-Adult,
pubmed-meshheading:20679526-Aged,
pubmed-meshheading:20679526-Aged, 80 and over,
pubmed-meshheading:20679526-Chemokines,
pubmed-meshheading:20679526-Cluster Analysis,
pubmed-meshheading:20679526-Cytogenetic Analysis,
pubmed-meshheading:20679526-Female,
pubmed-meshheading:20679526-Humans,
pubmed-meshheading:20679526-Leukemia, Myeloid, Acute,
pubmed-meshheading:20679526-Male,
pubmed-meshheading:20679526-Middle Aged,
pubmed-meshheading:20679526-Multivariate Analysis,
pubmed-meshheading:20679526-Myelodysplastic Syndromes,
pubmed-meshheading:20679526-Principal Component Analysis,
pubmed-meshheading:20679526-Prognosis,
pubmed-meshheading:20679526-Survival Analysis,
pubmed-meshheading:20679526-Treatment Outcome,
pubmed-meshheading:20679526-Young Adult
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Recurrent expression signatures of cytokines and chemokines are present and are independently prognostic in acute myelogenous leukemia and myelodysplasia.
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| pubmed:affiliation |
Department of Leukemia, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA. skornblau@mdanderson.org
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| pubmed:publicationType |
Journal Article
|