Linked Life Data

20677091

Source:http://linkedlifedata.com/resource/pubmed/id/20677091

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-8-2
pubmed:abstractText
The use of viruses as therapeutic agents against cancer is an old concept that has had a significant revival in the past two decades, in parallel with advances in methods to modify viral genomes genetically. From the initial stage of proof of concept, the field of virotherapy quickly progressed to the clinical setting, where serious limitations, yet promising opportunities, were identified. After demonstrating good safety profiles in humans, the objective in virotherapy has become to improve the efficacy of oncolytic viruses. Virotherapy approaches include incorporating therapeutic genes, evaluating alternative viruses with stronger oncolytic potential, employing new methods to improve biodistribution, and establishing greater insight into the influence of the immune system on both the success and failure of therapies. This review summarizes the most significant advances in recent years in the design of virotherapy for effective tumor treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
2040-3445
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
403-11
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Design of virotherapy for effective tumor treatment.
pubmed:affiliation
University of Navarra, Center for Applied Medical Research, Gene Therapy Unit, Avenue Pio XII 55, 31008 Pamplona, Spain. rubenh@unav.es
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't