|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2010-8-26
|
|
pubmed:abstractText |
We found the voltage-gated K+ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2-/- (also known as Kcnh3-/-) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-10191308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-11181977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-11425889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-12193184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-14527270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-14651847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-15608631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-1585183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-17167098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-17615350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-18071155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-18719581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-19149488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-19923296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20676103-5157749
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1546-1726
|
|
pubmed:author |
pubmed-author:AvisJacquelineJ,
pubmed-author:BaumgärtelKarstenK,
pubmed-author:BertasoFedericaF,
pubmed-author:CienfuegosCynthiaC,
pubmed-author:ClancySinead MSM,
pubmed-author:DaguiaCatherineC,
pubmed-author:HunyhTrucT,
pubmed-author:JeglaTimothyT,
pubmed-author:NoebelsJeffreyJ,
pubmed-author:SchmedtChristianC,
pubmed-author:TanL BLB,
pubmed-author:WilmotCarlyC,
pubmed-author:YooJong WJW,
pubmed-author:ZhangXiaofeiX
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1056-8
|
|
pubmed:dateRevised |
2011-7-25
|
|
pubmed:meshHeading |
pubmed-meshheading:20676103-Action Potentials,
pubmed-meshheading:20676103-Animals,
pubmed-meshheading:20676103-Cell Line,
pubmed-meshheading:20676103-Cells, Cultured,
pubmed-meshheading:20676103-Convulsants,
pubmed-meshheading:20676103-Epilepsy,
pubmed-meshheading:20676103-Ether-A-Go-Go Potassium Channels,
pubmed-meshheading:20676103-Female,
pubmed-meshheading:20676103-Hippocampus,
pubmed-meshheading:20676103-Humans,
pubmed-meshheading:20676103-Male,
pubmed-meshheading:20676103-Membrane Potentials,
pubmed-meshheading:20676103-Mice,
pubmed-meshheading:20676103-Mice, Inbred C57BL,
pubmed-meshheading:20676103-Mice, Knockout,
pubmed-meshheading:20676103-Neurons,
pubmed-meshheading:20676103-Pentylenetetrazole,
pubmed-meshheading:20676103-Pyramidal Cells,
pubmed-meshheading:20676103-Seizures,
pubmed-meshheading:20676103-Video Recording,
pubmed-meshheading:20676103-Xenopus
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy.
|
|
pubmed:affiliation |
Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
