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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-10-11
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pubmed:abstractText |
Epothilone B (EpoB), like Taxol, stabilizes microtubules resulting in an inhibition of microtubule dynamic instability. The drug is being evaluated in phase III clinical trials. An EpoB analog, Ixabepilone, was approved by the FDA for the treatment of taxane-resistant metastatic breast cancer. Epithelial cell adhesion antigen (EpCAM) expression is significantly higher in epithelial ovarian cancer cells compared to normal cells. The effects of EpoB and other microtubule-interacting agents on surface EpCAM expression were studied.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkanes,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Carbamates,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/EPCAM protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Epothilones,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxamic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Lactones,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrones,
http://linkedlifedata.com/resource/pubmed/chemical/Tubulin,
http://linkedlifedata.com/resource/pubmed/chemical/Tubulin Modulators,
http://linkedlifedata.com/resource/pubmed/chemical/Vinblastine,
http://linkedlifedata.com/resource/pubmed/chemical/discodermolide,
http://linkedlifedata.com/resource/pubmed/chemical/epothilone B,
http://linkedlifedata.com/resource/pubmed/chemical/trichostatin A
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1095-6859
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
345-50
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pubmed:dateRevised |
2011-11-1
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pubmed:meshHeading |
pubmed-meshheading:20674962-Acetylation,
pubmed-meshheading:20674962-Alkanes,
pubmed-meshheading:20674962-Antigens, Neoplasm,
pubmed-meshheading:20674962-Carbamates,
pubmed-meshheading:20674962-Cell Adhesion Molecules,
pubmed-meshheading:20674962-Cell Line, Tumor,
pubmed-meshheading:20674962-Epothilones,
pubmed-meshheading:20674962-Female,
pubmed-meshheading:20674962-Humans,
pubmed-meshheading:20674962-Hydroxamic Acids,
pubmed-meshheading:20674962-Lactones,
pubmed-meshheading:20674962-Ovarian Neoplasms,
pubmed-meshheading:20674962-Paclitaxel,
pubmed-meshheading:20674962-Pyrones,
pubmed-meshheading:20674962-Tubulin,
pubmed-meshheading:20674962-Tubulin Modulators,
pubmed-meshheading:20674962-Vinblastine
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pubmed:year |
2010
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pubmed:articleTitle |
Epothilone B enhances surface EpCAM expression in ovarian cancer Hey cells.
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pubmed:affiliation |
Division of Gynecologic Oncology, Department of Obstetrics & Gynecology and Women's Health, Montefiore Medical Center Bronx, NY 10461, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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