Source:http://linkedlifedata.com/resource/pubmed/id/20674684
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2010-9-13
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| pubmed:abstractText |
To elucidate whether interleukin-18 (IL-18) or interferon-? (IFN-?) participates in neurodegeneartion, we investigated the changes in IL-18 and IFN-? systems within the rat hippocampus following status epilepticus (SE). In non-SE induced animals, IL-18, IL-18 receptor ? (IL-18R?), IFN-? and IFN-? receptor ? (IFN-?R?) immunoreactivity was not detected in the hippocampus. Following SE, IL-18 immunoreactivity was increased in CA1-3 pyramidal cells as well as dentate granule cells. IL-18 immunoreactivity was also up-regulated in astrocytes and microglia/macrophages. IL-18R? immunoreactivity was detected in astrocytes and microglia/macrophages. IFN-? immunoreactivity was detected only in astrocytes within all regions of the hippocampus. IFN-?R? immunoreactivity was increased in neurons as well as astrocytes. Intracerebroventricular infusions of recombinant rat IL-18 or IFN-? alleviated SE-induced neuronal damages, while neutralization of IL-18, IFN-? or their receptors aggravated them, as compared to saline-infused animals. These findings suggest that astroglial-mediated IFN-? pathway in response to IL-18 induction may play an important role in alleviation of SE-induced neuronal damages.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18 Receptor alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Pilocarpine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interferon,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/interferon gamma receptor
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1873-7544
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
27
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| pubmed:volume |
170
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
711-21
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:20674684-Animals,
pubmed-meshheading:20674684-Astrocytes,
pubmed-meshheading:20674684-Disease Models, Animal,
pubmed-meshheading:20674684-Hippocampus,
pubmed-meshheading:20674684-Infusions, Intraventricular,
pubmed-meshheading:20674684-Interferon-gamma,
pubmed-meshheading:20674684-Interleukin-18,
pubmed-meshheading:20674684-Interleukin-18 Receptor alpha Subunit,
pubmed-meshheading:20674684-Male,
pubmed-meshheading:20674684-Microglia,
pubmed-meshheading:20674684-Nerve Degeneration,
pubmed-meshheading:20674684-Neurons,
pubmed-meshheading:20674684-Pilocarpine,
pubmed-meshheading:20674684-Rats,
pubmed-meshheading:20674684-Rats, Sprague-Dawley,
pubmed-meshheading:20674684-Receptors, Interferon,
pubmed-meshheading:20674684-Recombinant Proteins,
pubmed-meshheading:20674684-Status Epilepticus,
pubmed-meshheading:20674684-Up-Regulation
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| pubmed:year |
2010
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| pubmed:articleTitle |
The protective effects of interleukin-18 and interferon-? on neuronal damages in the rat hippocampus following status epilepticus.
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| pubmed:affiliation |
Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chunchon, Kangwon-DO 200-702, South Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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