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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5991
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pubmed:dateCreated |
2010-7-30
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pubmed:databankReference |
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pubmed:abstractText |
During embryonic development, many organs form by extensive branching of epithelia through the formation of clefts and buds. In cleft formation, buds are delineated by the conversion of epithelial cell-cell adhesions to cell-matrix adhesions, but the mechanisms of cleft formation are not clear. We have identified Btbd7 as a dynamic regulator of branching morphogenesis. Btbd7 provides a mechanistic link between the extracellular matrix and cleft propagation through its highly focal expression leading to local regulation of Snail2 (Slug), E-cadherin, and epithelial cell motility. Inhibition experiments show that Btbd7 is required for branching of embryonic mammalian salivary glands and lungs. Hence, Btbd7 is a regulatory gene that promotes epithelial tissue remodeling and formation of branched organs.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
329
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
562-5
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pubmed:dateRevised |
2010-8-31
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pubmed:meshHeading |
pubmed-meshheading:20671187-Amino Acid Sequence,
pubmed-meshheading:20671187-Animals,
pubmed-meshheading:20671187-Cadherins,
pubmed-meshheading:20671187-Cell Adhesion,
pubmed-meshheading:20671187-Cell Line,
pubmed-meshheading:20671187-Cell Movement,
pubmed-meshheading:20671187-Dogs,
pubmed-meshheading:20671187-Epithelial Cells,
pubmed-meshheading:20671187-Fibronectins,
pubmed-meshheading:20671187-Genes, Regulator,
pubmed-meshheading:20671187-Lung,
pubmed-meshheading:20671187-Mice,
pubmed-meshheading:20671187-Mice, Inbred ICR,
pubmed-meshheading:20671187-Models, Biological,
pubmed-meshheading:20671187-Molecular Sequence Data,
pubmed-meshheading:20671187-Morphogenesis,
pubmed-meshheading:20671187-Organ Culture Techniques,
pubmed-meshheading:20671187-Proteins,
pubmed-meshheading:20671187-RNA, Small Interfering,
pubmed-meshheading:20671187-Salivary Glands,
pubmed-meshheading:20671187-Submandibular Gland,
pubmed-meshheading:20671187-Transcription Factors,
pubmed-meshheading:20671187-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Btbd7 regulates epithelial cell dynamics and branching morphogenesis.
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pubmed:affiliation |
Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4370, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
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