Linked Life Data

20670989

Source:http://linkedlifedata.com/resource/pubmed/id/20670989

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-6-22
pubmed:abstractText
Three hundred 1-day-old Avian broilers were divided into four groups and fed on control diet (fluorine 23 mg/kg) and high-fluorine (F) diets (400 mg/kg, high-F group I; 800 mg/kg, high-F group II; 1200 mg/kg, high-F group III) for 42 days (n = 75/group). The growth index (GI) was obviously decreased in the three high-F groups, which indicated the inhibited development of thymus. Histopathologically, the population of thymocytes was decreased in the thymic lobule in the three high-F groups. As measured by flow cytometry, thymocytes in G(0)/G(1) phase were significantly increased while thymocytes in S phase, G(2) + M phase and proliferating index (PI) value were obviously decreased in the three high-F groups. Also, the percentage of apoptotic thymocytes was greatly increased in the three high-F groups when compared with that of control group. At the same time, the occurrence frequencies of apoptotic thymocyte were markedly increased in the three high-F groups, with the appearance of dilated endoplasmic reticulum in high-F groups II and III ultra-structurally. The results showed that excess dietary F in the range of 400-1200 mg/kg caused histological lesions, G(0)/G(1) arrest and cellular apoptosis in the thymus, which inhibited the development of thymus and finally led to impaired cellular immune function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1477-0903
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
685-92
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Cell-cycle blockage associated with increased apoptotic cells in the thymus of chickens fed on diets high in fluorine.
pubmed:affiliation
Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an, Sichuan, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't