Linked Life Data

20670011

Source:http://linkedlifedata.com/resource/pubmed/id/20670011

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2010-7-30
pubmed:abstractText
The preparation of 3,3-disubstituted oxindoles by a formal C-H, Ar-H coupling of anilides is described. Highly efficient conditions have been identified using catalytic (5 mol %) Cu(OAc)(2).H(2)O with atmospheric oxygen as the reoxidant; no additional base is required, and the reaction can be run in toluene or mesitylene. Optimization studies are reported together with a scope and limitation investigation based on variation of the anilide precursors. The application of this methodology to prepare a key intermediate for the total synthesis of the anticancer, analgesic oxindole alkaloid Horsfiline is also described.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1523-7052
pubmed:author
pubmed:issnType
Electronic
pubmed:day
6
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3446-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
First C-H activation route to oxindoles using copper catalysis.
pubmed:affiliation
Department of Chemistry, University of York, Heslington, York, YO10 5DD, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't