Linked Life Data

20668908

Source:http://linkedlifedata.com/resource/pubmed/id/20668908

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2010-10-18
pubmed:abstractText
Motor neuron diseases (MNDs) are a group of neurological disorders that selectively affect motor neurons. There are currently no cures or efficacious treatments for these diseases. In recent years, significant developments in stem cell research have been applied to MNDs, particularly regarding neuroprotection and cell replacement. However, a consistent source of motor neurons for cell replacement is required. Human embryonic stem cells (hESCs) could provide an inexhaustible supply of differentiated cell types, including motor neurons that could be used for MND therapies. Recently, it has been demonstrated that induced pluripotent stem (iPS) cells may serve as an alternative source of motor neurons, since they share ES characteristics, self-renewal, and the potential to differentiate into any somatic cell type. In this review, we discuss several reproducible methods by which hESCs or iPS cells are efficiently isolated and differentiated into functional motor neurons, and possible clinical applications.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1420-9071
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3837-47
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells.
pubmed:affiliation
Department of Neurological Sciences, Dino Ferrari Centre, University of Milan, Istituto di Ricovero e Cura a Carattere Scientifico Foundation, Milan, Italy. monica.nizzardo@unimi.it
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't