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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-12-30
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pubmed:abstractText |
The hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation. This is preceded by upregulation of CD86 on resident airway dendritic cells (DCs) that normally lack competence in T-cell triggering. Moreover, AHR duration is controlled via T-regulatory (Treg) cells, which can attenuate CD86 upregulation on DC. We show that airway mucosal Treg/DC interaction represents an accessible therapeutic target for asthma control. Notably, baseline airway Treg activity in sensitized rats can be boosted by microbe-derived stimulation of the gut, resulting in enhanced capacity to control CD86 expression on airway DC triggered by aeroallergen and accelerated resolution of AHR.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1935-3456
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
43-52
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pubmed:meshHeading |
pubmed-meshheading:20668438-Animals,
pubmed-meshheading:20668438-Antigens, CD86,
pubmed-meshheading:20668438-Asthma,
pubmed-meshheading:20668438-Bacteria,
pubmed-meshheading:20668438-Bronchial Hyperreactivity,
pubmed-meshheading:20668438-CD4-Positive T-Lymphocytes,
pubmed-meshheading:20668438-Cell Extracts,
pubmed-meshheading:20668438-Cytokines,
pubmed-meshheading:20668438-Dendritic Cells,
pubmed-meshheading:20668438-Disease Models, Animal,
pubmed-meshheading:20668438-Forkhead Transcription Factors,
pubmed-meshheading:20668438-Gastrointestinal Tract,
pubmed-meshheading:20668438-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:20668438-Rats,
pubmed-meshheading:20668438-Respiratory System,
pubmed-meshheading:20668438-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:20668438-T-Lymphocytes, Regulatory
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pubmed:year |
2011
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pubmed:articleTitle |
Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control.
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pubmed:affiliation |
Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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