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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-8-19
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pubmed:abstractText |
S-phase kinase-associated protein 2 (Skp2) is related to cellular proliferation and differentiation in laryngeal carcinoma. This study aimed to investigate the effect of Skp-2 suppression on p27 expression, cellular proliferation, apoptosis, and tumor growth in laryngeal squamous cell carcinoma. Skp2 was stably suppressed in Hep2 laryngeal carcinoma cells by lentivirus siRNA technology and Hep2-siRNA was then inoculated into nude mice. The siRNA-induced suppression of Skp2 increased p27 expression, decreased cellular proliferation, and increased apoptosis in human laryngeal carcinoma cells and tumors, indicating that Skp2 is a viable target in the gene therapy treatment of human laryngeal carcinoma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0275
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
205-14
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pubmed:meshHeading |
pubmed-meshheading:20668394-Animals,
pubmed-meshheading:20668394-Apoptosis,
pubmed-meshheading:20668394-Carcinoma, Squamous Cell,
pubmed-meshheading:20668394-Cell Proliferation,
pubmed-meshheading:20668394-Disease Models, Animal,
pubmed-meshheading:20668394-Female,
pubmed-meshheading:20668394-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20668394-Humans,
pubmed-meshheading:20668394-Immunohistochemistry,
pubmed-meshheading:20668394-Laryngeal Neoplasms,
pubmed-meshheading:20668394-Mice,
pubmed-meshheading:20668394-Polymerase Chain Reaction,
pubmed-meshheading:20668394-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:20668394-RNA, Small Interfering,
pubmed-meshheading:20668394-S-Phase Kinase-Associated Proteins,
pubmed-meshheading:20668394-Tumor Cells, Cultured
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pubmed:year |
2010
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pubmed:articleTitle |
Suppression of S-phase kinase-associated protein 2 induces apoptosis and inhibits tumor growth in human laryngeal cancer.
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pubmed:affiliation |
Department of Otorhinolaryngology, China Medical University Affiliated Shengjing Hospital, Shenyang, China.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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