Linked Life Data

20668009

Source:http://linkedlifedata.com/resource/pubmed/id/20668009

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-10-8
pubmed:abstractText
To determine whether inherited variations in immune function single-nucleotide polymorphisms (SNPs), genes or pathways affect glioblastoma risk, we analyzed data from recent genome-wide association studies in conjunction with predefined immune function genes and pathways. Gene and pathway analyses were conducted on two independent data sets using 6629 SNPs in 911 genes on 17 immune pathways from 525 glioblastoma cases and 602 controls from the University of California, San Francisco (UCSF) and a subset of 6029 SNPs in 893 genes from 531 cases and 1782 controls from MD Anderson (MDA). To further assess consistency of SNP-level associations, we also compared data from the UK (266 cases and 2482 controls) and the Mayo Clinic (114 cases and 111 controls). Although three correlated epidermal growth factor receptor (EGFR) SNPs were consistently associated with glioblastoma in all four data sets (Mantel-Haenzel P values = 1 × 10?? to 4 × 10?³), independent replication is required as genome-wide significance was not attained. In gene-level analyses, eight immune function genes were significantly (minP < 0.05) associated with glioblastoma; the IL-2RA (CD25) cytokine gene had the smallest minP values in both UCSF (minP = 0.01) and MDA (minP = 0.001) data sets. The IL-2RA receptor is found on the surface of regulatory T cells potentially contributing to immunosuppression characteristic of the glioblastoma microenvironment. In pathway correlation analyses, cytokine signaling and adhesion-extravasation-migration pathways showed similar associations with glioblastoma risk in both MDA and UCSF data sets. Our findings represent the first systematic description of immune genes and pathways that characterize glioblastoma risk.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1460-2180
pubmed:author
pubmed-author:BergerMitchel SMS, pubmed-author:BondyMelissa LML, pubmed-author:ChangJeffrey SJS, pubmed-author:ChangSusan MSM, pubmed-author:DeckerPaul APA, pubmed-author:DingBoB, pubmed-author:HepworthSarah JSJ, pubmed-author:HoskingFay JFJ, pubmed-author:HoulstonRichard SRS, pubmed-author:JenkinsRobert BRB, pubmed-author:KoselMatthew LML, pubmed-author:LiuYanhongY, pubmed-author:McCoyLucie SLS, pubmed-author:McKinneyPatricia APA, pubmed-author:MuirKennethK, pubmed-author:PatokaJoe SJS, pubmed-author:PradosMichaelM, pubmed-author:RiceTerriT, pubmed-author:RobertsonLindsay BLB, pubmed-author:SchoemakerMinouk JMJ, pubmed-author:SchwartzbaumJudith AJA, pubmed-author:SheteSanjayS, pubmed-author:SwerdlowAnthony JAJ, pubmed-author:TsavachidisSpyrosS, pubmed-author:WiemelsJoe LJL, pubmed-author:WienckeJohn KJK, pubmed-author:WrenschMargaret RMR, pubmed-author:XiaoYuanyuanY, pubmed-author:YangPingP
pubmed:issnType
Electronic
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1770-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Inherited variation in immune genes and pathways and glioblastoma risk.
pubmed:affiliation
Division of Epidemiology, College of Public Health, Ohio State University, Columbus, OH 43210, USA. jschwartzbaum@cph.osu.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural