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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-11-8
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pubmed:abstractText |
Previous experiments have shown that application of the anti-EGFR monoclonal antibody C225 (cetuximab) improves local tumour control after irradiation in FaDu human squamous cell carcinoma (hSCC) due to the combined effect of decreased repopulation and improved reoxygenation. The present study investigates early changes of the pimonidazole hypoxic fraction of FaDu tumours and the expression and phosphorylation of the EGFR and its downstream signal transduction molecules after treatment with C225 alone or in combination with irradiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1879-0887
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
322-9
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pubmed:meshHeading |
pubmed-meshheading:20667608-Animals,
pubmed-meshheading:20667608-Anoxia,
pubmed-meshheading:20667608-Antibodies, Monoclonal,
pubmed-meshheading:20667608-Carcinoma, Squamous Cell,
pubmed-meshheading:20667608-Cell Line, Tumor,
pubmed-meshheading:20667608-Combined Modality Therapy,
pubmed-meshheading:20667608-Dose Fractionation,
pubmed-meshheading:20667608-Female,
pubmed-meshheading:20667608-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20667608-Humans,
pubmed-meshheading:20667608-Male,
pubmed-meshheading:20667608-Mice,
pubmed-meshheading:20667608-Neoplasms,
pubmed-meshheading:20667608-Nitroimidazoles,
pubmed-meshheading:20667608-Radiation-Sensitizing Agents,
pubmed-meshheading:20667608-Receptor, Epidermal Growth Factor,
pubmed-meshheading:20667608-Signal Transduction,
pubmed-meshheading:20667608-Transplantation, Heterologous,
pubmed-meshheading:20667608-Xenograft Model Antitumor Assays
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pubmed:year |
2010
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pubmed:articleTitle |
Effect of cetuximab and fractionated irradiation on tumour micro-environment.
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pubmed:affiliation |
Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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