Linked Life Data

20667498

Source:http://linkedlifedata.com/resource/pubmed/id/20667498

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-8-26
pubmed:abstractText
Inflammatory response is involved in the etiopathology of Alzheimer's disease (AD). Interleukin-6 (IL-6), a pleiotropic inflammatory cytokine, was reported to be associated with both increased A beta aggregation and the appearance of hyperphosphorylated tau in AD brain. To explore the association of genetic variants in the promoter of IL-6 gene with sporadic AD (SAD), a case-control study was conducted in a North Chinese Han population. A systematic screening of IL-6 promoter was performed using direct sequencing and two polymorphisms were obtained including -572C/G (rs1800796) and -384A/T (rs7802308). Definitive genotyping of these markers and apolipoprotein E (APOE) polymorphism were surveyed in 341 SAD patients and 421 controls. The results revealed no significant differences in the distributions of alleles or genotypes between SAD and control groups. However, there was an interaction between -572C/G and APOE genotypes (P=0.016) using logistic analysis. In the subjects with APOE epsilon 4, there were significant differences in the allele (P=0.004) and genotype (P=0.004) distributions of -572C/G polymorphism between SAD and control groups. The -572CC genotype increased risk for AD by 3.301-fold (Wald=11.093, adjust OR=3.301, 95% CI=1.635-6.665, P=0.001) compared to CG+GG genotype. The present results suggest the -572 polymorphism could modify the risk for SAD in APOE epsilon 4 carriers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1872-7972
pubmed:author
pubmed:copyrightInfo
(c) 2010 Elsevier Ireland Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
4
pubmed:volume
482
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
260-3
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
The interleukin-6 gene -572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers.
pubmed:affiliation
Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't