Linked Life Data

20666496

Source:http://linkedlifedata.com/resource/pubmed/id/20666496

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-9-3
pubmed:abstractText
Chronic wounds associated with vascular disease, diabetes mellitus, or aging are leading causes of morbidity in western countries and represent an unresolved clinical problem. The development of innovative strategies to promote tissue repair is therefore an important task that requires a more thorough analysis of the underlying molecular pathophysiology. We propose that the understanding of the complex biological events that control tissue repair or its failure largely benefits from a broad analytical approach as provided by novel proteomic methodologies. Here we present the first comparative proteome analysis of wound exudates obtained from normal healing or nonhealing (venous leg ulcer) human skin wounds. A total of 149 proteins were identified with high confidence. A minority of proteins was exclusively present in exudate of the healing wound (23 proteins) or the nonhealing wound (26 proteins). Of particular interest was the differential distribution of specific proteins among the two different healing phenotypes. Whereas in the exudate obtained from the healing wound mediators characteristic for tissue formation were abundantly present, in the exudate obtained from the nonhealing wound numerous mediators characteristic for a persistent inflammatory and tissue destructive response were identified. Furthermore, the study also revealed interesting results regarding the identification of new proteins with yet unknown functions in skin repair. This analysis therefore represents an important basis for the search for potential biomarkers, which give rise to a better understanding and monitoring of disease progression in chronic wounds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1535-3907
pubmed:author
pubmed:issnType
Electronic
pubmed:day
3
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4758-66
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:20666496-Aged, pubmed-meshheading:20666496-Annexins, pubmed-meshheading:20666496-Biological Markers, pubmed-meshheading:20666496-Calgranulin B, pubmed-meshheading:20666496-Chronic Disease, pubmed-meshheading:20666496-Electrophoresis, Polyacrylamide Gel, pubmed-meshheading:20666496-Extracellular Matrix Proteins, pubmed-meshheading:20666496-Exudates and Transudates, pubmed-meshheading:20666496-Humans, pubmed-meshheading:20666496-Immunohistochemistry, pubmed-meshheading:20666496-Inflammation, pubmed-meshheading:20666496-Lactoferrin, pubmed-meshheading:20666496-Leg Ulcer, pubmed-meshheading:20666496-Middle Aged, pubmed-meshheading:20666496-Proteome, pubmed-meshheading:20666496-Proteomics, pubmed-meshheading:20666496-Reproducibility of Results, pubmed-meshheading:20666496-Wound Healing
pubmed:year
2010
pubmed:articleTitle
Differential proteomic analysis distinguishes tissue repair biomarker signatures in wound exudates obtained from normal healing and chronic wounds.
pubmed:affiliation
Department of Dermatology, Center for Molecular Medicine Cologne (CMMC), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Oral and Musculoskeletal Biology, University of Cologne, Cologne, Germany. sabine.eming@uni-koeln.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't