Linked Life Data

20665966

Source:http://linkedlifedata.com/resource/pubmed/id/20665966

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-7-27
pubmed:abstractText
A quantitative theory is developed for the relationship between stimulus and the resulting blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) signal, including both spatial and temporal dynamics for the first time. The brain tissue is modeled as a porous elastic medium, whose interconnected pores represent the vasculature. The model explicitly incorporates conservation of blood mass, interconversion of oxygenated and deoxygenated hemoglobin, force balance within the blood and of blood pressure with vessel walls, and blood flow modulation due to neuronal activity. In appropriate limits it is shown to reproduce prior Balloon models of hemodynamic response, which do not include spatial variations. The regime of validity of such models is thereby clarified by elucidating their assumptions, and when these break down, for example when voxel sizes become small.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1095-8541
pubmed:author
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
265
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
524-34
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Spatiotemporal BOLD dynamics from a poroelastic hemodynamic model.
pubmed:affiliation
School of Physics, University of Sydney, NSW 2006, Australia. p.drysdale@physics.usyd.edu.au
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't