Linked Life Data

20664896

Source:http://linkedlifedata.com/resource/pubmed/id/20664896

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-9-2
pubmed:abstractText
Endothelial microparticles (EMP) are complex vesicular structures that can be shed by activated or apoptotic endothelial cells. EMP are composed of a phospholipid bilayer that exposes transmembrane proteins and receptors and encloses cytosolic components such as enzymes, transcription factors and mRNA derived from their parent cells. Thus, EMP behave as biological conveyors playing a key role in the tuning of vascular homeostasis. This review focuses on the multifaceted roles of EMP, notably in coagulation, inflammation and angiogenesis and also on the mechanisms that trigger their formation. In this context, EMP could compromise vascular homeostasis and then represent key players in the pathogenesis of several inflammatory and thrombotic diseases. Consequently, elucidating their role and their mechanisms of formation will bring new insights into the understanding of endothelial-associated diseases. Moreover, in the future, it can open novel therapeutic perspectives based on the inhibition of EMP release.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0340-6245
pubmed:author
pubmed:issnType
Print
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
456-63
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Endothelial-derived microparticles: Biological conveyors at the crossroad of inflammation, thrombosis and angiogenesis.
pubmed:affiliation
Laboratoire de Physiopathologie de l'Endothélium - UMR_S 608 INSERM, Université de la Mediterranée, Marseille, France.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't