Source:http://linkedlifedata.com/resource/pubmed/id/20663521
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2010-8-12
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pubmed:abstractText |
The availability of various transgenic and knockout mice provides an excellent opportunity to better understand the pathophysiology of calcium oxalate stone disease. However, attempts to produce calcium oxalate nephrolithiasis in mice have not been successful. We hypothesized that calcium oxalate nephrolithiasis in mice requires increasing urine calcium and oxalate excretion, and experimentally induced hyperoxaluria alone is not sufficient. To provide evidence we induced hyperoxaluria by administering hyperoxaluria inducing agents in normocalciuric and hypercalciuric mice, and investigating various aspects of nephrolithiasis.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Oxalate,
http://linkedlifedata.com/resource/pubmed/chemical/Ethylene Glycol,
http://linkedlifedata.com/resource/pubmed/chemical/Glyoxylates,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyproline,
http://linkedlifedata.com/resource/pubmed/chemical/glyoxylic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1527-3792
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pubmed:author | |
pubmed:copyrightInfo |
2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
184
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1189-96
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pubmed:meshHeading |
pubmed-meshheading:20663521-Animals,
pubmed-meshheading:20663521-Calcium Oxalate,
pubmed-meshheading:20663521-Disease Models, Animal,
pubmed-meshheading:20663521-Ethylene Glycol,
pubmed-meshheading:20663521-Female,
pubmed-meshheading:20663521-Glyoxylates,
pubmed-meshheading:20663521-Hydroxyproline,
pubmed-meshheading:20663521-Male,
pubmed-meshheading:20663521-Mice,
pubmed-meshheading:20663521-Nephrolithiasis
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pubmed:year |
2010
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pubmed:articleTitle |
Experimental induction of calcium oxalate nephrolithiasis in mice.
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pubmed:affiliation |
Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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