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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-7-28
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pubmed:abstractText |
Neuronal events leading to development of long-term potentiation (LTP) in the nociceptive pathways may be a cellular mechanism underlying hyperalgesia. In the present study, we examine if induction of spinal LTP may be associated with functional changes in the supraspinal opioidergic system. The opioid receptors (ORs) play a key role in nociceptive processing and controlling the descending modulatory system to the spinal cord.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1475-097X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
285-93
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pubmed:meshHeading |
pubmed-meshheading:20662879-Animals,
pubmed-meshheading:20662879-Brain,
pubmed-meshheading:20662879-Electric Stimulation,
pubmed-meshheading:20662879-Evoked Potentials,
pubmed-meshheading:20662879-Female,
pubmed-meshheading:20662879-Long-Term Potentiation,
pubmed-meshheading:20662879-Morphinans,
pubmed-meshheading:20662879-Nerve Fibers, Unmyelinated,
pubmed-meshheading:20662879-Neural Pathways,
pubmed-meshheading:20662879-Pain,
pubmed-meshheading:20662879-Positron-Emission Tomography,
pubmed-meshheading:20662879-Radiopharmaceuticals,
pubmed-meshheading:20662879-Rats,
pubmed-meshheading:20662879-Rats, Sprague-Dawley,
pubmed-meshheading:20662879-Receptors, Opioid,
pubmed-meshheading:20662879-Sciatic Nerve,
pubmed-meshheading:20662879-Synaptic Transmission,
pubmed-meshheading:20662879-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Spinal long-term potentiation is associated with reduced opioid neurotransmission in the rat brain.
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pubmed:affiliation |
Centre for Molecular Biology and Neuroscience & Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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