Source:http://linkedlifedata.com/resource/pubmed/id/20662561
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2010-10-26
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| pubmed:abstractText |
Nonsyndromic cleft lip with or without cleft palate (nsCL/P) has a complex etiology, which involves both genetic and environmental factors. In this study, we carried out mutation screening of the poliovirus receptor related-2 (PRR2) gene, located at an orofacial cleft (OFC) linkage region 19q13 (OFC3). PRR2 Sau96I (A/G) genotypes of 212 patients with nsCLP and 221 controls were detected using a polymerase chain reaction-restriction fragment length polymerase assay. The results showed significant differences in the genotype and allele distribution of the PRR2 Sau96I (A/G) between the cases and controls. The GG genotype resulted in a significantly raised odds ratio (OR) compared with the AA genotype (OR=3.031; 95% confidence interval: 1.601, 5.742). The G allele showed a significant elevated risk (?(2)?= 26.991, p=0.000, OR=2.147; 95% confidence interval: 1.605, 2.871) compared with the A allele. Hence, our results support the hypothesis that this polymorphism contributes to the risk of nsCL/P, suggesting a possible etiologic role of PRR2 in nsCL/P.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1557-7430
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
29
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
681-5
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| pubmed:meshHeading |
pubmed-meshheading:20662561-Adolescent,
pubmed-meshheading:20662561-Base Sequence,
pubmed-meshheading:20662561-Cell Adhesion Molecules,
pubmed-meshheading:20662561-Child,
pubmed-meshheading:20662561-Child, Preschool,
pubmed-meshheading:20662561-Chromosomes, Human, Pair 19,
pubmed-meshheading:20662561-Cleft Lip,
pubmed-meshheading:20662561-Cleft Palate,
pubmed-meshheading:20662561-Female,
pubmed-meshheading:20662561-Gene Frequency,
pubmed-meshheading:20662561-Genetic Association Studies,
pubmed-meshheading:20662561-Genetic Predisposition to Disease,
pubmed-meshheading:20662561-Genotype,
pubmed-meshheading:20662561-Humans,
pubmed-meshheading:20662561-Infant,
pubmed-meshheading:20662561-Male,
pubmed-meshheading:20662561-Odds Ratio,
pubmed-meshheading:20662561-Polymorphism, Single Nucleotide
|
| pubmed:year |
2010
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| pubmed:articleTitle |
Association analysis of the poliovirus receptor related-2 gene in patients with nonsyndromic cleft lip with or without cleft palate.
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| pubmed:affiliation |
Department of Chemical Examination, Baise People's Hospital, Baise, Guangxi, China. hcl_2010@yahoo.cn
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| pubmed:publicationType |
Journal Article
|