Linked Life Data

20661604

Source:http://linkedlifedata.com/resource/pubmed/id/20661604

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2010-11-3
pubmed:abstractText
A relationship between chronic hepatitis C virus (HCV) infection and interleukin-10 (IL-10) gene polymorphisms has been reported with controversial results in different studies. In an effort to solve this controversy, we quantitatively summarized ten studies on this relationship by means of meta-analysis. Our analysis included ten case-control studies with 992 cases of chronic HCV infection and 1,123 controls. Analyses were performed with STATA version 9.0. The results showed that the IL-10 -1082GG genotype significantly increased the risk for persistent HCV infection (AA vs. GG: OR = 0.680, 95% CI = 0.489-0.947, P = 0.022; AG vs. GG: OR = 0.608, 95% CI = 0.439-0.840, P = 0.003; GG vs. AG + AA: OR = 1.570, 95% CI = 1.160-2.123, P = 0.003), but no statistically significant differences were observed between cases and controls for IL-10 -819C/T and IL-10 -592C/A polymorphisms (P > 0.05). In conclusion, this meta-analysis suggested that the IL-10 -1082GG genotype was associated with increased susceptibility for chronic HCV infection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1432-8798
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
155
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1839-42
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Interleukin-10 gene polymorphisms in association with susceptibility to chronic hepatitis C virus infection: a meta-analysis study.
pubmed:affiliation
Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Meta-Analysis