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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
32
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pubmed:dateCreated |
2010-8-11
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pubmed:abstractText |
The production of blood cells depends on a rare hematopoietic stem-cell (HSC) population, but the molecular mechanisms underlying HSC biology remain incompletely understood. Here, we identify a subset of microRNAs (miRNAs) that is enriched in HSCs compared with other bone-marrow cells. An in vivo gain-of-function screen found that three of these miRNAs conferred a competitive advantage to engrafting hematopoietic cells, whereas other HSC miRNAs attenuated production of blood cells. Overexpression of the most advantageous miRNA, miR-125b, caused a dose-dependent myeloproliferative disorder that progressed to a lethal myeloid leukemia in mice and also enhanced hematopoietic engraftment in human immune system mice. Our study identifies an evolutionarily conserved subset of miRNAs that is expressed in HSCs and functions to modulate hematopoietic output.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-12228720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-12434020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-12714971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-15064419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-15143321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-15867090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-15989959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-16009718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-16304059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-16633340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-16641092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-17293455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-17589498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-17923094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-18278031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-18295580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-18299402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-18329371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-18385684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-18936236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-19255566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-19345332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-19359473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-19379700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-19632182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-20054295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-20060366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-20098459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-20194440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-20212066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20660734-20425795
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14235-40
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pubmed:dateRevised |
2011-7-25
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pubmed:meshHeading |
pubmed-meshheading:20660734-Animals,
pubmed-meshheading:20660734-Bone Marrow Cells,
pubmed-meshheading:20660734-Dose-Response Relationship, Drug,
pubmed-meshheading:20660734-Gene Expression Regulation,
pubmed-meshheading:20660734-Graft Survival,
pubmed-meshheading:20660734-Hematopoiesis,
pubmed-meshheading:20660734-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:20660734-Hematopoietic Stem Cells,
pubmed-meshheading:20660734-Humans,
pubmed-meshheading:20660734-Leukemia, Myeloid,
pubmed-meshheading:20660734-Mice,
pubmed-meshheading:20660734-Mice, Transgenic,
pubmed-meshheading:20660734-MicroRNAs,
pubmed-meshheading:20660734-Myeloproliferative Disorders
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pubmed:year |
2010
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pubmed:articleTitle |
MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output.
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pubmed:affiliation |
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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