Source:http://linkedlifedata.com/resource/pubmed/id/20659128
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-9-13
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| pubmed:abstractText |
Activation of the alpha7 receptor (?7nAChR) has been shown to be important in inflammation and immune regulation, and is also essential in the neural cholinergic anti-inflammatory pathway. The aim of this study was to investigate the role of ?7nAChR in the development of experimental arthritis and immune activation. Mice lacking the ?7nAChR were immunized with collagen II and the development of arthritis was assessed. Another group of ?7nAChR-deficient mice was immunized with ovalbumin, spleen and lymph node cells were isolated and the proliferative responses to restimulation with ovalbumin or concanavalin A were investigated. We could demonstrate significantly milder arthritis and less cartilage destruction, together with a decrease of T cell content in lymph nodes in mice lacking the ?7nAChR compared to wild-type controls. In addition, mice lacking the ?7nAChR had a deficient proliferative response to concanavalin A, whereas antigen presentation-dependent proliferation was not affected. These results indicate important roles for ?7nAChR in arthritis development as well as in regulation of T cell-dependent immunological mechanisms. In addition, the data implicate ?7nAChR as a therapeutic target for modulation of adaptive immune responses.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Concanavalin A,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogens,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nicotinic,
http://linkedlifedata.com/resource/pubmed/chemical/alpha7 nicotinic acetylcholine...
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1365-2249
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| pubmed:author | |
| pubmed:copyrightInfo |
© 2010 The Authors. Clinical and Experimental Immunology © 2010 British Society for Immunology.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
162
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
62-7
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| pubmed:dateRevised |
2011-10-3
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| pubmed:meshHeading |
pubmed-meshheading:20659128-Adaptive Immunity,
pubmed-meshheading:20659128-Animals,
pubmed-meshheading:20659128-Arthritis, Experimental,
pubmed-meshheading:20659128-Cartilage, Articular,
pubmed-meshheading:20659128-Cell Proliferation,
pubmed-meshheading:20659128-Concanavalin A,
pubmed-meshheading:20659128-Female,
pubmed-meshheading:20659128-Flow Cytometry,
pubmed-meshheading:20659128-Lymph Nodes,
pubmed-meshheading:20659128-Male,
pubmed-meshheading:20659128-Mice,
pubmed-meshheading:20659128-Mice, Inbred C57BL,
pubmed-meshheading:20659128-Mice, Knockout,
pubmed-meshheading:20659128-Mitogens,
pubmed-meshheading:20659128-Ovalbumin,
pubmed-meshheading:20659128-Receptors, Nicotinic,
pubmed-meshheading:20659128-Severity of Illness Index,
pubmed-meshheading:20659128-Spleen,
pubmed-meshheading:20659128-Synovitis,
pubmed-meshheading:20659128-T-Lymphocytes
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| pubmed:year |
2010
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| pubmed:articleTitle |
Lack of acetylcholine nicotine alpha 7 receptor suppresses development of collagen-induced arthritis and adaptive immunity.
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| pubmed:affiliation |
Karolinska Institute, Department of Medicine, Unit of Rheumatology, CMM:04, Karolinska University Hospital, Stockholm, Sweden.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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