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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-7-27
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pubmed:abstractText |
We previously developed a transgenic Caenorhabditis elegans model of human tauopathy disorders by expressing human tau in nematode worm neurons to explore genetic pathways contributing to tau-induced neurodegeneration. This animal model recapitulates several hallmarks of human tauopathies, including altered behaviour, accumulation of detergent-insoluble phosphorylated tau protein and neurodegeneration. To identify genes required for tau neurotoxicity, we carried out a forward genetic screen for mutations that suppress tau neurotoxicity. We ultimately cloned the sut-2 (suppressor of tau pathology-2) gene, mutations in which alleviate tau neurotoxicity in C. elegans. SUT-2 encodes a novel subtype of CCCH zinc-finger protein conserved across animal phyla. SUT-2 shares significant identity with the mammalian SUT-2 (MSUT-2). We identified components of the aggresome as binding partners of MSUT-2. Thus we hypothesize that MSUT-2 plays a role in the formation and/or clearance of protein aggregates. We are currently exploring the role of MSUT-2 in tauopathy using mammalian systems. The identification of sut-2 as a gene required for tau neurotoxicity in C. elegans suggests new neuroprotective strategies targeting MSUT-2 that may be effective in modulating tau neurotoxicity in human tauopathy disorders.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20658987-10100846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20658987-10214944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20658987-10359094,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20658987-9927460
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1470-8752
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
973-6
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pubmed:dateRevised |
2011-8-3
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pubmed:meshHeading |
pubmed-meshheading:20658987-Animals,
pubmed-meshheading:20658987-Animals, Genetically Modified,
pubmed-meshheading:20658987-Caenorhabditis elegans,
pubmed-meshheading:20658987-Caenorhabditis elegans Proteins,
pubmed-meshheading:20658987-Carrier Proteins,
pubmed-meshheading:20658987-Disease Models, Animal,
pubmed-meshheading:20658987-Drug Delivery Systems,
pubmed-meshheading:20658987-Humans,
pubmed-meshheading:20658987-Models, Biological,
pubmed-meshheading:20658987-Nerve Degeneration,
pubmed-meshheading:20658987-Neuroprotective Agents,
pubmed-meshheading:20658987-Nuclear Proteins,
pubmed-meshheading:20658987-RNA-Binding Proteins,
pubmed-meshheading:20658987-Tauopathies
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pubmed:year |
2010
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pubmed:articleTitle |
The role of MSUT-2 in tau neurotoxicity: a target for neuroprotection in tauopathy?
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pubmed:affiliation |
Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle Division, 1660 S Colombian Way, Seattle, WA 98108, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Review,
Research Support, N.I.H., Extramural
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