Linked Life Data

20658475

Source:http://linkedlifedata.com/resource/pubmed/id/20658475

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-3-7
pubmed:abstractText
Multiple myeloma (MM) is a B-cell lymphoid malignancy suspected to be associated with immunologic factors. Given recent findings associating single-nucleotide polymorphisms (SNPs) in innate immunity genes with non-Hodgkin lymphoma, we conducted an investigation of innate immune gene variants using specimens from a population-based case-control study of MM conducted in Connecticut women. Tag SNPs (N?=?1461) summarizing common variation in 149 gene regions were genotyped in non-Hispanic Caucasian subjects (103 cases, 475 controls). Odds ratios (OR) and 95% confidence intervals (CI) relating SNP associations with MM were computed using unconditional logistic regression, while the MinP test was used to investigate associations with MM at the gene level. We calculated permutation-adjusted P-values and false discovery rates (FDR) to account for the number of comparisons performed in SNP-level and gene-level tests, respectively. Three genes were associated with MM when controlling for a FDR of ?10%: SERPINE1 (P(MinP) ?<?0.0001; FDR?=?0.02), CCR7 (P(MinP) ?=?0.0006; FDR?=?0.06) and HGF (P(MinP) ?=?0.001; FDR?=?0.08). Two SNPs demonstrated robust associations: SERPINE1 rs2227667 (P?=?2.1?×?10(-5) , P(permutation) ?=?0.03) and HGF rs17501108 (P?=?5.0?×?10(-5) , P(permutation) ?=?0.07). Our findings suggest that genetic variants in SERPINE1 and HGF, and possibly CCR7, are associated with MM risk, and warrant further investigation in other studies.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1099-1069
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 John Wiley & Sons, Ltd.
pubmed:issnType
Electronic
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
42-6
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Variation in innate immunity genes and risk of multiple myeloma.
pubmed:affiliation
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH/DHHS, Bethesda, MD, USA. purduem@mail.nih.gov
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural