Source:http://linkedlifedata.com/resource/pubmed/id/20656316
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2010-10-18
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| pubmed:abstractText |
Posttransplantation lymphoproliferative disorders (PTLD) are heterogeneous lesions with variable morphology, immunophenotype, and molecular characteristics. Multiple distinct primary lesions can occur in PTLD, rarely with both B-cell and T-cell characteristics. Lesions can involve both grafted organs and other sites; however, PTLD involving the pituitary gland has not been previously reported. We describe a patient who developed Epstein-Barr virus-negative PTLD 13 years posttransplantation involving the terminal ileum and pituitary, which was simultaneously involved by a pituitary adenoma. Immunohistochemistry of the pituitary lesion showed expression of CD79a, CD3, and CD7 with clonal rearrangements of both T-cell receptor gamma chain (TRG@) and immunoglobulin heavy chain (IGH@) genes. The terminal ileal lesion was immunophenotypically and molecularly distinct. This is the first report of pituitary PTLD and illustrates the potentially complex nature of PTLD.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1532-8392
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
|
| pubmed:issnType |
Electronic
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| pubmed:volume |
41
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1641-5
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| pubmed:meshHeading |
pubmed-meshheading:20656316-Adenoma,
pubmed-meshheading:20656316-Adult,
pubmed-meshheading:20656316-Antigens, CD,
pubmed-meshheading:20656316-Clone Cells,
pubmed-meshheading:20656316-Fatal Outcome,
pubmed-meshheading:20656316-Female,
pubmed-meshheading:20656316-Gene Rearrangement, B-Lymphocyte, Heavy Chain,
pubmed-meshheading:20656316-Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor,
pubmed-meshheading:20656316-Humans,
pubmed-meshheading:20656316-Ileum,
pubmed-meshheading:20656316-Immunoglobulin Heavy Chains,
pubmed-meshheading:20656316-Immunohistochemistry,
pubmed-meshheading:20656316-Lung Transplantation,
pubmed-meshheading:20656316-Lymphoproliferative Disorders,
pubmed-meshheading:20656316-Pituitary Diseases,
pubmed-meshheading:20656316-Pituitary Gland,
pubmed-meshheading:20656316-Pituitary Neoplasms,
pubmed-meshheading:20656316-Postoperative Complications
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Posttransplantation lymphoproliferative disease involving the pituitary gland.
|
| pubmed:affiliation |
Department of Pathology, University of Virginia Health System, PO Box 800214, Charlottesville, VA 22908, USA.
|
| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|