Source:http://linkedlifedata.com/resource/pubmed/id/20655350
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2010-9-17
|
| pubmed:abstractText |
Genetic polymorphisms of interleukin-6 (IL-6) (-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C) may affect the outcomes of several diseases. This study was aimed to verify the role of these polymorphisms on the disease progression of patients with hepatitis C virus (HCV) infection and persistently normal transaminases (PNALT). A total of 121 PNALT patients did not receive any antiviral treatment but underwent periodic clinical monitoring, including repeat biopsies, for a median of 120 months. IL6-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C polymorphisms were related to histologic fibrosis progression. Among patients whose grading and staging scores increased at the end of the follow-up ?2 Ishak points (N = 60 and N = 26, respectively), IL-6 -174G>C genotype frequencies were GG 37/66, GC 21/45, CC 2/10 (p = 0.041) and GG 18/66, GC 8/45, CC 0/10 (p = 0.040), respectively. The following frequencies were observed for the 572G>C polymorphism: GG 50/105, GC 10/16, CC 0/0, and GG 19/105, GC 7/16, CC 0/0, respectively. Grading progression was independently associated with carriage of the G allele in -174G>C polymorphism (oddd ratio = 5.07%, 95% confidence interval = 0.959-26.8, p = 0.023). Staging progression was independently associated with carriage of the C allele in -572G>C polymorphism (odd ratio = 4.60%, 95% confidence interval 1.42-14.8, p = 0.012). IL-6 polymorphisms influence histologic progression of HCV in patients with PNALT.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1879-1166
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| pubmed:author |
pubmed-author:BitettoDavideD,
pubmed-author:CmetSaraS,
pubmed-author:CollettaCosimoC,
pubmed-author:CussighAnnarosaA,
pubmed-author:FabrisCarloC,
pubmed-author:FalletiEdmondoE,
pubmed-author:FontaniniElisabettaE,
pubmed-author:MinisiniRosalbaR,
pubmed-author:PirisiMarioM,
pubmed-author:SmirneCarloC,
pubmed-author:ToniuttoPierluigiP,
pubmed-author:VandelliCarmenC
|
| pubmed:copyrightInfo |
2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
999-1004
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| pubmed:meshHeading |
pubmed-meshheading:20655350-Adolescent,
pubmed-meshheading:20655350-Adult,
pubmed-meshheading:20655350-Child,
pubmed-meshheading:20655350-Disease Progression,
pubmed-meshheading:20655350-Female,
pubmed-meshheading:20655350-Follow-Up Studies,
pubmed-meshheading:20655350-Gene Frequency,
pubmed-meshheading:20655350-Genotype,
pubmed-meshheading:20655350-Hepatitis C, Chronic,
pubmed-meshheading:20655350-Humans,
pubmed-meshheading:20655350-Interleukin-6,
pubmed-meshheading:20655350-Liver Cirrhosis,
pubmed-meshheading:20655350-Male,
pubmed-meshheading:20655350-Middle Aged,
pubmed-meshheading:20655350-Polymorphism, Genetic
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Genetic polymorphisms of interleukin-6 modulate fibrosis progression in mild chronic hepatitis C.
|
| pubmed:affiliation |
Medical Liver Transplant Unit, University of Udine, Undine, Italy.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|