Linked Life Data

2065354

Source:http://linkedlifedata.com/resource/pubmed/id/2065354

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1991-8-13
pubmed:abstractText
Yeast cells choose bud sites on their surface in two distinct spatial patterns: axial for a and alpha cells and bipolar for a/alpha cells. We have identified four genes, BUD1-BUD4, necessary for the axial pattern by isolating mutants of alpha cells that do not exhibit this pattern. Mutations in BUD1 (which is the same as the previously identified gene RSR1) or BUD2 lead to a random budding pattern in all cell types; mutations in BUD3 or BUD4 lead to a bipolar pattern in all cell types. These observations indicate the existence of a basal budding pattern, requiring no BUD products, that is random; BUD1 and BUD2 act on this basal pattern to create the bipolar pattern; the further action of BUD3 and BUD4 leads to the axial pattern. These studies thus identify a set of gene products that directs cell morphogenesis to a genetically programmed site.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
65
pubmed:geneSymbol
BUD1, BUD2, BUD3, BUD4, BUD5, RSR1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1203-12
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway.
pubmed:affiliation
Department of Biochemistry and Biophysics, University of California, San Francisco 94143.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't