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pubmed-article:2065312pubmed:abstractTextA 64-year-old woman presented with a platelet count of 3,225 x 10(9)/L. Bone marrow morphology showed massive megakaryocytic hyperplasia; cytogenetic studies showed the presence of the Philadelphia chromosome (Ph). The presence of a rearrangement involving the major breakpoint cluster region (mbcr) on chromosome 22 was confirmed by Southern blotting techniques. A diagnosis of Ph positive essential thrombocythemia (ET) was made. Such cases constitute less than 5% of patients with ET and it has been proposed that they be considered examples of chronic myelogenous leukemia (CML) because of a shared propensity to progress to blast crisis. An argument is presented for retaining Ph positive ET as an entity separate from Ph negative ET and Ph positive CML.lld:pubmed
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pubmed-article:2065312pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:2065312pubmed:articleTitleEssential thrombocythemia with the Philadelphia chromosome and BCR-ABL gene rearrangement. An entity distinct from chronic myeloid leukemia and Philadelphia chromosome-negative essential thrombocythemia.lld:pubmed
pubmed-article:2065312pubmed:affiliationDepartment of Laboratory Haematology, Sunnybrook Medical Centre, Toronto, Ontario, Canada.lld:pubmed
pubmed-article:2065312pubmed:publicationTypeJournal Articlelld:pubmed