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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-8-13
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pubmed:abstractText |
A 64-year-old woman presented with a platelet count of 3,225 x 10(9)/L. Bone marrow morphology showed massive megakaryocytic hyperplasia; cytogenetic studies showed the presence of the Philadelphia chromosome (Ph). The presence of a rearrangement involving the major breakpoint cluster region (mbcr) on chromosome 22 was confirmed by Southern blotting techniques. A diagnosis of Ph positive essential thrombocythemia (ET) was made. Such cases constitute less than 5% of patients with ET and it has been proposed that they be considered examples of chronic myelogenous leukemia (CML) because of a shared propensity to progress to blast crisis. An argument is presented for retaining Ph positive ET as an entity separate from Ph negative ET and Ph positive CML.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0165-4608
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2065312-Blotting, Southern,
pubmed-meshheading:2065312-Bone Marrow,
pubmed-meshheading:2065312-Chromosomes, Human, Pair 9,
pubmed-meshheading:2065312-DNA, Neoplasm,
pubmed-meshheading:2065312-Diagnosis, Differential,
pubmed-meshheading:2065312-Female,
pubmed-meshheading:2065312-Humans,
pubmed-meshheading:2065312-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:2065312-Middle Aged,
pubmed-meshheading:2065312-Protein-Tyrosine Kinases,
pubmed-meshheading:2065312-Proto-Oncogene Proteins,
pubmed-meshheading:2065312-Proto-Oncogene Proteins c-bcr,
pubmed-meshheading:2065312-Thrombocythemia, Essential,
pubmed-meshheading:2065312-Translocation, Genetic
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pubmed:year |
1991
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pubmed:articleTitle |
Essential thrombocythemia with the Philadelphia chromosome and BCR-ABL gene rearrangement. An entity distinct from chronic myeloid leukemia and Philadelphia chromosome-negative essential thrombocythemia.
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pubmed:affiliation |
Department of Laboratory Haematology, Sunnybrook Medical Centre, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article
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