Source:http://linkedlifedata.com/resource/pubmed/id/20652381
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2010-11-3
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| pubmed:abstractText |
Accumulating evidences indicate that killer cell immunoglobulin-like receptors (KIRs) and their corresponding specific HLA-C ligands contribute to the pathogenesis of multiple autoimmune diseases via the modulation of natural killer (NK) cell and T cell functions. The present study was performed to investigate whether the polymorphism of KIR genes and HLA ligands associates with the susceptibility of ankylosing spondylitis (AS). Previous studies have demonstrated a strong association between HLA-B27 gene and the pathogenesis of AS. In this study, 115 unrelated HLA-B27-positive AS patients and 119 HLA-B27-positive healthy controls were recruited. Polymerase chain reaction using sequence-specific primers was used to determine the genotypes of KIR genes and HLA-C alleles. The results showed that the frequencies of KIR2DL1 and KIR2DL5 were significantly higher in the AS patient group than those in the control group (p = 0.012 and p = 0.009, respectively). Meanwhile, individuals with AS showed an increased frequency of HLA-Cw*08 (p = 0.001, p (c)? = 0.008) compared with that in controls. Our findings indicate that with the genetic background of HLA-B27, variation at the KIRs and their corresponding specific HLA-C ligands may influence the ability of NK cells and T cells to recognize and lyse targets in immune responses, which thereby contributes to pathogenesis of AS.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
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| pubmed:issn |
1573-2592
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
30
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
840-4
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| pubmed:meshHeading |
pubmed-meshheading:20652381-Adolescent,
pubmed-meshheading:20652381-Adult,
pubmed-meshheading:20652381-Aged,
pubmed-meshheading:20652381-Child,
pubmed-meshheading:20652381-DNA Mutational Analysis,
pubmed-meshheading:20652381-Female,
pubmed-meshheading:20652381-Gene Frequency,
pubmed-meshheading:20652381-Genetic Association Studies,
pubmed-meshheading:20652381-Genetic Predisposition to Disease,
pubmed-meshheading:20652381-Genotype,
pubmed-meshheading:20652381-HLA-B27 Antigen,
pubmed-meshheading:20652381-HLA-C Antigens,
pubmed-meshheading:20652381-Humans,
pubmed-meshheading:20652381-Male,
pubmed-meshheading:20652381-Middle Aged,
pubmed-meshheading:20652381-Polymorphism, Genetic,
pubmed-meshheading:20652381-Receptors, KIR,
pubmed-meshheading:20652381-Spondylitis, Ankylosing
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis.
|
| pubmed:affiliation |
Central Laboratory, Provincial Hospital affiliated to Shandong University, Jinan 250021, People's Republic of China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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