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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-9-16
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pubmed:abstractText |
A central function of the endothelium is to serve as a selective barrier that regulates fluid and solute exchange. Although perturbation of barrier function can contribute to numerous disease states, our understanding of the molecular mechanisms regulating this aspect of endothelial biology remains incompletely understood. Accumulating evidence implicates the Kruppel-like factor 2 (KLF2) as a key regulator of endothelial function. However, its role in vascular barrier function is unknown.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/HL084154,
http://linkedlifedata.com/resource/pubmed/grant/HL086548,
http://linkedlifedata.com/resource/pubmed/grant/HL086668,
http://linkedlifedata.com/resource/pubmed/grant/HL087595,
http://linkedlifedata.com/resource/pubmed/grant/HL088740,
http://linkedlifedata.com/resource/pubmed/grant/HL097023,
http://linkedlifedata.com/resource/pubmed/grant/HL72952,
http://linkedlifedata.com/resource/pubmed/grant/HL75427,
http://linkedlifedata.com/resource/pubmed/grant/HL76754,
http://linkedlifedata.com/resource/pubmed/grant/K01 HL088740-05,
http://linkedlifedata.com/resource/pubmed/grant/P01 HL48743,
http://linkedlifedata.com/resource/pubmed/grant/R00 HL087595-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL086548-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL097593-02
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/KLF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Klf2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Kruppel-Like Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myosin Light Chains,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombin,
http://linkedlifedata.com/resource/pubmed/chemical/occludin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4636
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pubmed:author |
pubmed-author:AtkinsG BrandonGB,
pubmed-author:CuiYingjieY,
pubmed-author:DrewM AMA,
pubmed-author:FiniganJames HJH,
pubmed-author:HallJ CJC,
pubmed-author:JainMukesh KMK,
pubmed-author:KawanamiDaijiD,
pubmed-author:LinZhiyongZ,
pubmed-author:MahabeleshwarGanapati HGH,
pubmed-author:NatesanViswanathV,
pubmed-author:NayakLalithaL
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pubmed:issnType |
Electronic
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1952-9
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pubmed:dateRevised |
2011-10-3
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pubmed:meshHeading |
pubmed-meshheading:20651277-Animals,
pubmed-meshheading:20651277-Capillary Permeability,
pubmed-meshheading:20651277-Cells, Cultured,
pubmed-meshheading:20651277-Endothelial Cells,
pubmed-meshheading:20651277-Gene Expression,
pubmed-meshheading:20651277-Humans,
pubmed-meshheading:20651277-Hydrogen Peroxide,
pubmed-meshheading:20651277-Kruppel-Like Transcription Factors,
pubmed-meshheading:20651277-Membrane Proteins,
pubmed-meshheading:20651277-Mice,
pubmed-meshheading:20651277-Mice, Knockout,
pubmed-meshheading:20651277-Myosin Light Chains,
pubmed-meshheading:20651277-Phosphorylation,
pubmed-meshheading:20651277-RNA, Messenger,
pubmed-meshheading:20651277-RNA, Small Interfering,
pubmed-meshheading:20651277-Recombinant Proteins,
pubmed-meshheading:20651277-Thrombin,
pubmed-meshheading:20651277-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Kruppel-like factor 2 regulates endothelial barrier function.
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pubmed:affiliation |
University Hospitals Harrington-McLaughlin Heart and Vascular Institute and Case Cardiovascular Research Institute, Cleveland, OH 44106-7290, USA. zhiyong.lin@case.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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