| pubmed-article:20650990 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20650990 | lifeskim:mentions | umls-concept:C0024128 | lld:lifeskim |
| pubmed-article:20650990 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:20650990 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:20650990 | lifeskim:mentions | umls-concept:C0038891 | lld:lifeskim |
| pubmed-article:20650990 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:20650990 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20650990 | pubmed:dateCreated | 2011-4-1 | lld:pubmed |
| pubmed-article:20650990 | pubmed:abstractText | The aim of this study was to investigate whether intratracheal administration of a new synthetic surfactant that includes the cationic, hydrophobic 21-residue peptide KLLLLKLLLLKLLLLKLLLLK (KL?), might be effective in reducing ischaemia-reperfusion injury after lung transplantation. Single left lung transplantation was performed in Landrace pigs 22 h post-harvest. KL? surfactant at a dose of 25 mg total phospholipid·kg body weight?¹ (2.5 mL·kg body weight?¹) was instilled at 37°C to the donor left lung (n = 8) prior to explantation. Saline (2.5 mL·kg body weight?¹; 37°C) was instilled into the donor left lung of the untreated group (n = 6). Lung function in recipients was measured during 2 h of reperfusion. Recipient left lung bronchoalveolar lavage (BAL) provided native cytometric, inflammatory marker and surfactant data. KL(4) surfactant treatment recovered oxygen levels in the recipient blood (mean ± sd arterial oxygen tension/inspiratory oxygen fraction 424 ± 60 versus 263 ± 101 mmHg in untreated group; p=0.01) and normalised alveolar-arterial oxygen tension difference. Surfactant biophysical function was also recovered in KL? surfactant-treated lungs. This was associated with decreased C-reactive protein levels in BAL, and recovery of surfactant protein A content, normalised protein/phospholipid ratios, and lower levels of both lipid peroxides and protein carbonyls in large surfactant aggregates. These findings suggest an important protective role for KL? surfactant treatment in lung transplantation. | lld:pubmed |
| pubmed-article:20650990 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20650990 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20650990 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20650990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20650990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20650990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20650990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20650990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20650990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20650990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20650990 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20650990 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20650990 | pubmed:issn | 1399-3003 | lld:pubmed |
| pubmed-article:20650990 | pubmed:author | pubmed-author:SegalRR | lld:pubmed |
| pubmed-article:20650990 | pubmed:author | pubmed-author:SantosMM | lld:pubmed |
| pubmed-article:20650990 | pubmed:author | pubmed-author:Castillo-Oliv... | lld:pubmed |
| pubmed-article:20650990 | pubmed:author | pubmed-author:AlvarezLL | lld:pubmed |
| pubmed-article:20650990 | pubmed:author | pubmed-author:CasalsCC | lld:pubmed |
| pubmed-article:20650990 | pubmed:author | pubmed-author:SáenzAA | lld:pubmed |
| pubmed-article:20650990 | pubmed:author | pubmed-author:VarelaAA | lld:pubmed |
| pubmed-article:20650990 | pubmed:author | pubmed-author:López-Sánchez... | lld:pubmed |
| pubmed-article:20650990 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20650990 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:20650990 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20650990 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20650990 | pubmed:pagination | 925-32 | lld:pubmed |
| pubmed-article:20650990 | pubmed:meshHeading | pubmed-meshheading:20650990... | lld:pubmed |
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| pubmed-article:20650990 | pubmed:meshHeading | pubmed-meshheading:20650990... | lld:pubmed |
| pubmed-article:20650990 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:20650990 | pubmed:articleTitle | Beneficial effects of synthetic KL? surfactant in experimental lung transplantation. | lld:pubmed |
| pubmed-article:20650990 | pubmed:affiliation | Dept of Biochemistry and Molecular Biology I, Complutense University and CIBERES (Respiratory Research Center), Madrid, Spain. | lld:pubmed |
| pubmed-article:20650990 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20650990 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
