Linked Life Data

20650596

Source:http://linkedlifedata.com/resource/pubmed/id/20650596

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-8-30
pubmed:abstractText
Hypernatremia invariably denotes hyperosmolarity and, at least transiently, causes cellular dehydration. Because of blood brain barrier properties, cerebral tissue volume is modified by acute changes in osmolarity. An acute hyperosmolarity (by intravenous sodium or mannitol) temporally decreases intracranial pressure. This treatment is thus useful in critical situations, allowing time for diagnosis and, if possible, other treatment. But in cases of sustained hypernatremia, cellular dehydration is rapidly counterbalanced by an increase in cellular osmolarity. For the brain, it has been shown that cerebral volume is restored in a few hours during prolonged hypernatremia. Moreover, the plasmatic osmotic load induces an increase in diuresis and natriuresis. A tight control is then necessary to prevent hypovolemia and electrolytes disorders. Teams using this treatment should undertake controlled randomized studies to ascertain any beneficial effect that cannot be explained by physiology.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1769-6623
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e189-92
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
[Hypernatremia in neurointensive care].
pubmed:affiliation
Département d'anesthésie-réanimation, CHU de Bicêtre, AP-HP, Le Kremlin-Bicêtre, France. bernard.vigue@bct.aphp.fr
pubmed:publicationType
Journal Article, English Abstract