Source:http://linkedlifedata.com/resource/pubmed/id/20649761
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2010-7-23
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| pubmed:abstractText |
A total of 959 Taiwanese patients undergoing maintenance hemodialysis-102 underweight (BMI < 18.5 kg/m(2)), 492 normal weight (BMI 18.5-22.9 kg/m(2)), 187 overweight (BMI 23.0-24.9 kg/m(2)), and 178 obese (BMI >or= 25 kg/m(2)) were recruited into this three-year, multicenter longitudinal study. It was found initially that the underweight group had more females, longer hemodialysis durations, less use of a biocompatible membrane (BCM) dialyzer, higher erythropoietin doses and Kt/V(urea), and lower white blood cell counts, hemoglobin, serum creatinine and phosphate, and high sensitivity C-reactive protein (hsCRP) than other groups (P < 0.001). Furthermore, a chi(2)-test demonstrated that underweight patients had poorer nutrition (P = 0.023), but less systemic inflammation (P < 0.001) than other groups. A stepwise multiple linear regression analysis established that age, sex, diabetes mellitus, hemodialysis duration, use of BCM dialyzer, Kt/V(urea), creatinine, high-density lipoprotein cholesterol, and hsCRP were significant risk factors associated with BMI (P < 0.001-0.002). After three years, 149 (15.5%) patients had died, including 22 of 102 (21.6%) underweight patients, 64 of 492 (13.0%) normal weight patients, 38 of 187 (20.3%) overweight patients, and 25 of 178 (15.5%) obese patients. The primary causes of mortality were cardiovascular (52.3%) and infection (39.6%). A multivariate Cox regression analysis revealed that age, diabetes mellitus, BMI, albumin, hsCRP, and cardiothoracic ratio were significant risk factors associated with all-cause mortality over three years (P < 0.001-0.022). Finally, Kaplan-Meier analysis confirmed that underweight patients suffer higher mortality than other groups (Log rank, P = 0.0392); therefore, the data have demonstrated a survival disadvantage of low BMI in Taiwanese patients undergoing maintenance hemodialysis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1744-9987
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
1
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| pubmed:volume |
14
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
400-8
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:20649761-Adult,
pubmed-meshheading:20649761-Aged,
pubmed-meshheading:20649761-Body Mass Index,
pubmed-meshheading:20649761-Cardiovascular Diseases,
pubmed-meshheading:20649761-Female,
pubmed-meshheading:20649761-Humans,
pubmed-meshheading:20649761-Infection,
pubmed-meshheading:20649761-Kaplan-Meier Estimate,
pubmed-meshheading:20649761-Kidney Failure, Chronic,
pubmed-meshheading:20649761-Linear Models,
pubmed-meshheading:20649761-Longitudinal Studies,
pubmed-meshheading:20649761-Male,
pubmed-meshheading:20649761-Middle Aged,
pubmed-meshheading:20649761-Multivariate Analysis,
pubmed-meshheading:20649761-Proportional Hazards Models,
pubmed-meshheading:20649761-Prospective Studies,
pubmed-meshheading:20649761-Renal Dialysis,
pubmed-meshheading:20649761-Risk Factors,
pubmed-meshheading:20649761-Taiwan,
pubmed-meshheading:20649761-Thinness
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| pubmed:year |
2010
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| pubmed:articleTitle |
Association between body mass and mortality in maintenance hemodialysis patients.
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| pubmed:affiliation |
Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan. m19570@adm.cgmh.org.tw
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| pubmed:publicationType |
Journal Article,
Multicenter Study
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