Source:http://linkedlifedata.com/resource/pubmed/id/20649559
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-10-5
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| pubmed:abstractText |
14q-deletions have been repeatedly described in mature B-cell neoplasms, but not yet characterized in a larger cohort. Based on chromosome banding analysis, the present study identified 47 del(14q) cases in 3054 mature B-cell neoplasms (1·5%) (chronic lymphocytic leukaemia [CLL]: 1·9%; CLL/prolymphocytic leukaemia [PL]: 9·0%; others: 0·2%). Interphase fluorescence in situ hybridization was performed with probes for 14q22.1, 14q24.1, 14q32.33, and IGH@ (14q32.3). The del(14q) had heterogeneous size but showed a breakpoint cluster at the centromeric site in 14q24.1 (62% of cases). At the telomeric side, the most frequent breakpoint was within the IGH@ locus (14q32.3) between IGH@ 3'-flanking and IGHV (IgVH) probes (45%). In 16 cases (34%), breakpoints occurred within 14q24.1 and 14q32.3. Eighty-one percent of del(14q) cases showed 1-3 additional cytogenetic alterations (in 45%, +12), and 56% were IGHV-unmutated. In all cases (16/16) with breakpoints in 14q24.1 and 14q32.3, a B-CLL immunophenotype was found. Clinical follow-up in 32 del(14q) patients was compared to 383 CLL and CLL/PL patients without del(14q). While 3-year-overall survival did not differ significantly, time to treatment was significantly shorter in the del(14q) cohort (21·0 months vs. 80·1 months, P = 0·015). In conclusion, the del(14q) is a rare recurrent alteration in diverse mature B-cell neoplasms, shows variable size but distinct clustering of breakpoints, and is associated with short time to treatment.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1365-2141
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| pubmed:author | |
| pubmed:copyrightInfo |
© 2010 Blackwell Publishing Ltd.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
151
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
25-36
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| pubmed:meshHeading |
pubmed-meshheading:20649559-Aged,
pubmed-meshheading:20649559-Aged, 80 and over,
pubmed-meshheading:20649559-Chromosome Aberrations,
pubmed-meshheading:20649559-Chromosome Deletion,
pubmed-meshheading:20649559-Chromosomes, Human, Pair 14,
pubmed-meshheading:20649559-Female,
pubmed-meshheading:20649559-Humans,
pubmed-meshheading:20649559-Immunoglobulin Heavy Chains,
pubmed-meshheading:20649559-Immunoglobulin Variable Region,
pubmed-meshheading:20649559-In Situ Hybridization, Fluorescence,
pubmed-meshheading:20649559-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:20649559-Leukemia, Prolymphocytic,
pubmed-meshheading:20649559-Male,
pubmed-meshheading:20649559-Middle Aged,
pubmed-meshheading:20649559-Mutation,
pubmed-meshheading:20649559-Prognosis,
pubmed-meshheading:20649559-Survival Analysis
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| pubmed:year |
2010
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| pubmed:articleTitle |
Biological and clinical characterization of recurrent 14q deletions in CLL and other mature B-cell neoplasms.
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| pubmed:affiliation |
Munich Leukemia Laboratory, Munich Interdisciplinary Clinic for Stem Cell Transplantation, Max-Lebsche-Platz 31, Munich, Germany.
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| pubmed:publicationType |
Journal Article
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