Linked Life Data

20648091

Source:http://linkedlifedata.com/resource/pubmed/id/20648091

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-8-13
pubmed:abstractText
Retinal degeneration encompasses a constellation of common pathologies for which there is no regenerative treatment. Vision loss has a devastating impact on quality of life and activities of daily living. Pharmacologic treatments serve to stave off disease progression but do not represent a restorative approach. Cellular transplantation is considered to be a promising approach for future therapy for retinal degeneration. There are, however, significant barriers that must be overcome if cell transplantation is to become a clinical reality. In this review, we focus on the need for a cellular replacement therapy for retinal disease and the promise of stem cells as candidate cellular therapeutics. In particular, we discuss the origins of stem cells in the retina, the discovery and characterization of retinal stem cells isolated from adult humans, and their transplantation potential and clinical implications.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0008-4182
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
342-51
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Biology and therapeutic potential of adult retinal stem cells.
pubmed:affiliation
Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ont.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural