Linked Life Data

20647026

Source:http://linkedlifedata.com/resource/pubmed/id/20647026

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-9-13
pubmed:abstractText
The basolateral amygdala is a nodal structure within a distributed and interconnected network that regulates anxiety states and anxiety-related behavior. Administration of multiple anxiogenic drugs increases cellular responses (i.e., increases c-Fos expression) in a subregion of the basolateral amygdala, but the neurochemical phenotypes of these cells are not known. The basolateral amygdala contains glutamatergic projection neurons and several populations of ?-aminobutyric acid-synthesizing (GABAergic) interneurons, including a population of parvalbumin (PV)-expressing GABAergic interneurons that co-express the excitatory 5-HT(2A) receptor. The role for these PV-expressing GABAergic interneurons in anxiety-states is unclear. In this experiment we examined the effects of multiple anxiogenic drugs including the 5-HT(2C/2A) receptor agonist m-chlorophenyl piperazine (mCPP), the adenosine receptor antagonist caffeine, the ?(2)-adrenoreceptor antagonist yohimbine and the partial inverse agonist at the benzodiazepine allosteric site on the GABA(A) receptor, N-methyl-beta-carboline-3-carboxamide (FG-7142), on c-Fos expression in PV-immunoreactive (PV-ir) interneurons in subdivisions of the basolateral amygdala. All drugs with the exception of mCPP increased c-Fos expression in PV-ir neurons in the basolateral amygdaloid nucleus, anterior part (BLA). The numbers of c-Fos-immunoreactive (c-Fos-ir)/PV-ir GABAergic interneurons in the BLA were positively correlated with the numbers of c-Fos-ir serotonergic neurons in the mid-rostrocaudal dorsal raphe nucleus (DR) and with a measure of anxiety-related behavior. All four drugs increased c-Fos expression in non-PV-ir cells in most of the subdivisions of the basolateral amygdala that were sampled, compared with vehicle-injected controls. Together, these data suggest that the PV/5-HT(2A) receptor expressing GABAergic interneurons in the basolateral amygdala are part of a DR-basolateral amygdala neuronal circuit modulating anxiety-states and anxiety-related behavior.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1878-4216
pubmed:author
pubmed:copyrightInfo
Published by Elsevier Inc.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1285-93
pubmed:dateRevised
2011-10-3
pubmed:meshHeading
pubmed-meshheading:20647026-Analysis of Variance, pubmed-meshheading:20647026-Animals, pubmed-meshheading:20647026-Anti-Anxiety Agents, pubmed-meshheading:20647026-Brain, pubmed-meshheading:20647026-Caffeine, pubmed-meshheading:20647026-Carbolines, pubmed-meshheading:20647026-Cell Count, pubmed-meshheading:20647026-Gene Expression Regulation, pubmed-meshheading:20647026-Interneurons, pubmed-meshheading:20647026-Male, pubmed-meshheading:20647026-Parvalbumins, pubmed-meshheading:20647026-Piperazines, pubmed-meshheading:20647026-Proto-Oncogene Proteins c-fos, pubmed-meshheading:20647026-Rats, pubmed-meshheading:20647026-Rats, Wistar, pubmed-meshheading:20647026-Receptor, Serotonin, 5-HT2A, pubmed-meshheading:20647026-Time Factors, pubmed-meshheading:20647026-Yohimbine, pubmed-meshheading:20647026-gamma-Aminobutyric Acid
pubmed:year
2010
pubmed:articleTitle
Multiple anxiogenic drugs recruit a parvalbumin-containing subpopulation of GABAergic interneurons in the basolateral amygdala.
pubmed:affiliation
Department of Integrative Physiology and Center for Neuroscience, University of Colorado, Boulder, CO, 80309-0354, USA. matthew.hale@colorado.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural