Linked Life Data

20646984

Source:http://linkedlifedata.com/resource/pubmed/id/20646984

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2010-9-27
pubmed:abstractText
Although the research on the potential regulation of human adrenal cortex by LH and hCG is still in its infancy, the available evidence supports the presence of very low levels of LH/hCG receptors in entire zona reticularis and deeper part of zona fasciculata. The activation of these receptors may lead to an increased secretion of androgens and/or cortisol. The same chronically elevated levels, along with unknown genetic and epigenetic changes, may also lead to the formation of tumors that can secrete all three major classes of adrenal steroid hormones. As shown in murine models, the increased receptor levels often seen in tumors, are probably caused by elevated LH/hCG levels. However, the elevated LH/hCG levels or their receptors alone may not be sufficient for the development of adrenal pathology. Therefore, further studies to advance our current understanding on the pathophysiology of human adrenal hCG/LH receptors are required.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1872-8057
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
25
pubmed:volume
329
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-6
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Human adrenal LH/hCG receptors and what they could mean for adrenal physiology and pathology.
pubmed:affiliation
Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA. crao@fiu.edu
pubmed:publicationType
Journal Article, Review