Linked Life Data

20644874

Source:http://linkedlifedata.com/resource/pubmed/id/20644874

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-7-20
pubmed:abstractText
Surface-enhanced Raman scattering (SERS) spectroscopy can be used for the label-free determination and quantification of relevant small biometabolites that are hard to identify by conventional immunological methods, in the absence of labelling. In this work, detection is based on monitoring the vibrational changes occurring at a specific biointerface (a monoclonal antibody, mAb) supported on silver-coated carbon nanotubes (CNT@Ag). Engineered CNT@Ag play a key role, as they offer a stable substrate to support the biointerface, with a high density of hot spots. Proof of concept is demonstrated through the analysis and quantification of the main cocaine metabolite benzoylecgonine. These results open a new avenue toward the generation of portable sensors for fast ultradetection and quantification of relevant metabolites. The use of discrete particles (CNT@Ag@mAb) rather than rough films, or other conventional SERS supports, will also enable a safe remote interrogation of highly toxic sources in environmental problems or in biological fluids.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
2040-3372
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153-8
pubmed:dateRevised
2011-6-22
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Label-free SERS detection of relevant bioanalytes on silver-coated carbon nanotubes: The case of cocaine.
pubmed:affiliation
Departamento de Química Física and Unidad Asociada CSIC, Universidade de Vigo, 36310 Vigo, Spain. macorrea@uvigo.es
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't