Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-7-20
pubmed:abstractText
In this report, we demonstrate that the internal disulfide bridge in human neuroglobin modulates structural changes associated with ligand photo-dissociation from the heme active site. This is evident from time-resolved photothermal studies of CO photo-dissociation, which reveal a 13.4+/-0.9 mL mol(-1) volume expansion upon ligand photo-release from human neuroglobin, whereas the CO dissociation from rat neuroglobin leads to a significantly smaller volume change (DeltaV=4.6+/-0.3 mL mol(-1)). Reduction of the internal disulfide bond in human neuroglobin leads to conformational changes (reflected by DeltaV) nearly identical to those observed for rat Ngb. Our data favor the hypothesis that the disulfide bond between Cys46 and Cys55 modulates the functioning of human neuroglobin.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20643048-11029004, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643048-12048231, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643048-12621155, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643048-12860983, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643048-12962627, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643048-14530264, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643048-15548613, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643048-17337004, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643048-17468165, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643048-17942367, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643048-17975837, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643048-19850865, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643048-19919085
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1542-0086
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
L16-8
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Probing the role of the internal disulfide bond in regulating conformational dynamics in neuroglobin.
pubmed:publicationType
Letter