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rdf:type |
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lifeskim:mentions |
umls-concept:C0015350,
umls-concept:C0017262,
umls-concept:C0022663,
umls-concept:C0027697,
umls-concept:C0034709,
umls-concept:C0040690,
umls-concept:C0083031,
umls-concept:C0185117,
umls-concept:C1280500,
umls-concept:C1514118,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2010-12-24
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pubmed:abstractText |
The effect of interleukin-11 (IL-11) on transforming growth factor-ß (TGF-ß) is controversial and has not been examined in renal diseases. In this study, we (i) characterised the up-regulation of TGF-ß1, phospho-p38 MAPK (p-p38 MAPK) and extracellular matrix during pathogenesis of glomerulonephritis and (ii) examined the effect of rhIL-11 on these processes in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fibronectins,
http://linkedlifedata.com/resource/pubmed/chemical/IL11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-11,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/antiglomerular basement membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/smooth muscle actin, rat
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pubmed:status |
MEDLINE
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pubmed:issn |
1724-6059
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
106-11
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pubmed:meshHeading |
pubmed-meshheading:20640990-Actins,
pubmed-meshheading:20640990-Animals,
pubmed-meshheading:20640990-Autoantibodies,
pubmed-meshheading:20640990-Disease Models, Animal,
pubmed-meshheading:20640990-Extracellular Matrix Proteins,
pubmed-meshheading:20640990-Fibronectins,
pubmed-meshheading:20640990-Glomerulonephritis,
pubmed-meshheading:20640990-Humans,
pubmed-meshheading:20640990-Interleukin-11,
pubmed-meshheading:20640990-Kidney Glomerulus,
pubmed-meshheading:20640990-Male,
pubmed-meshheading:20640990-Phosphorylation,
pubmed-meshheading:20640990-Rats,
pubmed-meshheading:20640990-Rats, Inbred WKY,
pubmed-meshheading:20640990-Recombinant Proteins,
pubmed-meshheading:20640990-Time Factors,
pubmed-meshheading:20640990-Transforming Growth Factor beta1,
pubmed-meshheading:20640990-p38 Mitogen-Activated Protein Kinases
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pubmed:articleTitle |
Effect of IL-11 on glomerular expression of TGF-beta and extracellular matrix in nephrotoxic nephritis in Wistar Kyoto rats.
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pubmed:affiliation |
Imperial College Kidney and Transplant Institute, Division of Medicine, Imperial College London, London, UK. Victoria.a.kumar@kp.org
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pubmed:publicationType |
Journal Article
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