Linked Life Data

20640438

Source:http://linkedlifedata.com/resource/pubmed/id/20640438

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-11-5
pubmed:abstractText
This study examined the effect of aerobic interval training on cardiac adaptations in VLCAD-deficient mice and determined the effects of the deficiency on the morphology and function of the left ventricle among 53 knockout homozygous VLCAD-/-, 28 heterozygous VLCAD±, and 39 controls VLCAD+/+ male mice (129 SvJ/C57BL6). Echocardiographic images were used to determine the left ventricular (LV) wall thicknesses, during systole and diastole, acquired at a depth setting of 20 mm. Cardiac hypertrophy (as evidenced by increased wall thickness, and decreased left ventricular dimension in diastole and systole) appeared to be a major finding in the VLCAD-/- mouse with, however, normal %FS. The trained mice from all three genotypes exhibited lower body weight compared with their controls. The echocardiographic data of this study demonstrated structural but not functional differences among the three genotypes. This study demonstrated that VLCAD± deficient mice handled interval training similarly to the non-deficient mice. Four VLCAD-/- deficient mice died unexpectedly on the treadmill during the early stages of training. The VLCAD-/- deficient mice that survived adapted to the aerobic interval training similarly to the non-deficient mice. It is unclear whether aerobic interval training is an appropriate training tool for the VLCAD-deficient humans.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1439-6327
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
110
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
915-23
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
The effects of aerobic interval training on the left ventricular morphology and function of VLCAD-deficient mice.
pubmed:affiliation
Department of Health Science, Kinesiology, Recreation, and Dance, University of Arkansas, HPER 308J, Fayetteville, AR 72701, USA. criggs@uark.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't