Source:http://linkedlifedata.com/resource/pubmed/id/20639491
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2010-8-5
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| pubmed:abstractText |
Robust Ab and CD4 T cell responses are required for the resolution of Salmonella infection in susceptible mice. In this study, we examined the role of B7-H1 (programmed cell death ligand 1) in resistance to primary Salmonella infection. Infected B7-H1-deficient mice had significantly higher bacterial burdens at day 21 and day 35 postinfection compared with wild-type mice, demonstrating that B7-H1 plays an important role in immunity to Salmonella. B7-H1-deficient and wild-type mice both generated Salmonella-specific IgM and IgG2c Ab responses to infection, and clonal expansion of endogenous and adoptively transferred Salmonella-specific CD4 T cells was similar in both groups. However, although Salmonella-specific IFN-gamma-producing Th1 CD4 T cells were generated in Salmonella-infected B7-H1-deficient mice, these cells did not expand to the level observed in wild-type mice. Furthermore, fewer multifunctional Th1 cells that simultaneously secreted IFN-gamma, TNF-alpha, and IL-2 were detected in Salmonella-infected B7-H1-deficient mice. Together, these data demonstrate that B7-H1 is required for the generation of multifunctional Th1 responses and optimal protective immunity to primary Salmonella infection.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD274,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Cd274 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
1550-6606
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
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| pubmed:volume |
185
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2442-9
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:20639491-Animals,
pubmed-meshheading:20639491-Antigens, CD274,
pubmed-meshheading:20639491-Antigens, CD80,
pubmed-meshheading:20639491-CD4-Positive T-Lymphocytes,
pubmed-meshheading:20639491-Cell Differentiation,
pubmed-meshheading:20639491-Cell Proliferation,
pubmed-meshheading:20639491-Clone Cells,
pubmed-meshheading:20639491-Flow Cytometry,
pubmed-meshheading:20639491-Immunity,
pubmed-meshheading:20639491-Lymphocyte Count,
pubmed-meshheading:20639491-Membrane Glycoproteins,
pubmed-meshheading:20639491-Mice,
pubmed-meshheading:20639491-Mice, Inbred C57BL,
pubmed-meshheading:20639491-Mice, Knockout,
pubmed-meshheading:20639491-Peptides,
pubmed-meshheading:20639491-Salmonella,
pubmed-meshheading:20639491-Salmonella Infections,
pubmed-meshheading:20639491-Survival Rate,
pubmed-meshheading:20639491-Th1 Cells,
pubmed-meshheading:20639491-Time Factors
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| pubmed:year |
2010
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| pubmed:articleTitle |
B7-H1 (programmed cell death ligand 1) is required for the development of multifunctional Th1 cells and immunity to primary, but not secondary, Salmonella infection.
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| pubmed:affiliation |
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Center for Infectious Diseases and Microbiology Translational Research, McGuire Translational Research Facility, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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